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DR CHRIS SOBEY



Contact Details

Organization: Pharmacology
Position: Honorary (Senior Fellow)
Email:

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 31-Dec-1987
Doctor of Philosophy University of Melbourne 31-Dec-1991

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Mechanisms of cerebrovascular regulation in health and disease Chief Investigator NHMRC R Douglas Wright Awards 01/01/2002
Nox4-containing NADPH-oxidase as a protective enzyme in the cerebral circulation Chief Investigator NHMRC Project Grants 01/01/2005
Initial appointment Research Fellow Level A Chief Investigator NHMRC Research Fellowship 01/01/2005
THE INVOLVEMENT OF NOX4-CONTAINING NADPH OXIDASE IN BRAIN PROTECTION FOLLOWING ISCHAEMIC STROKE Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2007

Contracts

Title Role Funding Source Award Date
A therapeutic & preventative cardiovascular treatment Chief Investigator RADICAL BIOTECHNOLOGY PTY LTD 20/10/2003

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries
    Year: 2007
    Journal: Brain Research
    Volume: 1141
    Page numbers: 99-107
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Publications in 2006

Journal Articles

  • Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase
    Year: 2006
    Journal: Journal of Cerebral Blood Flow and Metabolism
    Volume: 26
    Issue: 6
    Page numbers: 836-845
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  • NADPH-Induced Contractions of Mouse Aorta Do Not Involve NADPH Oxidase: A Role for P2X Receptors
    Year: 2006
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 317
    Issue: 2
    Page numbers: 644-650
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  • Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction
    Year: 2006
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 317
    Issue: 2
    Page numbers: 791-6
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  • Targeting Rho and Rho-kinase in the treatment of cardiovascular disease
    Year: 2006
    Journal: Trends in Pharmacological Sciences
    Volume: 27
    Issue: 2
    Page numbers: 97-104
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Publications in 2005

Journal Articles

  • NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
    Year: 2005
    Journal: Circulation Research
    Volume: 97
    Page numbers: 1055-1062
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasocontriction: Effects of rho-kinase and hypertension
    Year: 2005
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 313
    Issue: 3
    Page numbers: 1248-1253
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
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  • Selective inhibition of NADPH-oxidase isoforms as a therapeutic strategy in hypertension
    Year: 2005
    Journal: Drug Discovery Today
    Volume: 2
    Page numbers: 187-192
    Publisher: Elsevier, Trends Journals
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  • Signalling pathways activated by hydrogen peroxide in vascular smooth muscle
    Year: 2005
    Journal: Journal of Hypertension
    Volume: 23
    Page numbers: 1961-1962
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2004

Book Chapters

  • Vascular biology of atherosclerosis of cerebral arteries
    Year: 2004
    Book: Stroke: pathophysiology, diagnosis, and management
    Publisher: Churchill Livingstone(New York)
    Authors(s):

Journal Articles

  • Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice
    Year: 2004
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 287
    Page numbers: R342-R348
    Publisher: American Physiological Society(Maryland)
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  • Effect of short-term phytoestrogen treatment in male rats on nitric oxide-mediated responses of carotid and cerebral arteries: comparison with 17β-estradiol
    Year: 2004
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 310
    Page numbers: 135-140
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
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  • Evidence that estrogen suppresses Rho-kinase function in the cerebral circulation in vivo
    Year: 2004
    Journal: Stroke
    Volume: 35
    Page numbers: 2200-2205
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enchanced cerebral vasodilatation to NADPH in vivo
    Year: 2004
    Journal: Stroke
    Volume: 35
    Page numbers: 584-589
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  • Influence of gender on K+-induced cerebral vasodilation
    Year: 2004
    Journal: Stroke
    Volume: 35
    Page numbers: 747-752
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Reactive oxygen species in the cerebral circulation
    Year: 2004
    Journal: Drugs
    Volume: 64
    Issue: 19
    Page numbers: 2143-2157
    Publisher: Adis International(Bayauckland)
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Publications in 2003

Journal Articles

  • Bradykinin B2 receptor antagonism: a new direction for acute stroke therapy?
    Year: 2003
    Journal: British Journal of Pharmacology
    Volume: 139
    Page numbers: 1369-1371
    Publisher: Nature Publishing Group(Basingstroke)
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  • Cerebral vascular effects of reactive oxygen species: Recent evidence for a role of NADPH-oxidase
    Year: 2003
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 30
    Page numbers: 855-859
    Publisher: Blackwell Science Asia(Carlton)
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  • Inwardly rectifying potassium channels in the regulation of vascular tone
    Year: 2003
    Journal: Current Drug Targets
    Volume: 4
    Page numbers: 281-289
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  • Neurogenic atherosclerosis mediated by neuropeptide Y: Hardening of the evidence
    Year: 2003
    Journal: Arteriosclerosis Thrombosis and Vascular Biology
    Volume: 23
    Page numbers: 1137-1139
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2002

Journal Articles

  • Inhibitory effects of protein kinase C on inwardly rectifying K+- and ATP-Sensitive K+ channel-mediated responses of the basilar artery
    Year: 2002
    Journal: Stroke
    Volume: 33
    Page numbers: 1692-1697
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  • Neuronal NO mediates cerebral vasodilator responses to K+ in hypersensitive rats
    Year: 2002
    Journal: Hypertension
    Volume: 39
    Page numbers: 880-885
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Publications in 2001

Journal Articles

  • Arachidonate dilates basilar artery by lipoxygenase-dependent mechanisms and activation of K+ channels
    Year: 2001
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 281
    Page numbers: R246-R253
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  • Comment on: Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem
    Year: 2001
    Journal: Stroke
    Volume: 32
    Page numbers: 224
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  • Evidence that rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension. Comparison with protein kinase C
    Year: 2001
    Journal: Circulation Research
    Volume: 88
    Page numbers: 774-779
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  • Potassium channel function in vascular disease
    Year: 2001
    Journal: Arteriosclerosis Thrombosis and Vascular Biology
    Volume: 21
    Page numbers: 28-38
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Conference Publications/Papers

  • Cerebrovascular dysfunction after subarachnoid haemorrhage: novel mechanisms and directions for therapy
    Year: 2001
    Event name: 34th Annual Scientifc Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists
    Conference Publication: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 926-929
    Publisher: Blackwell Science Asia(Carlton)
    Author(s):
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