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PROF LEON BACH



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: Honorary (Professorial Fellow)
Email:

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Diabetic complications, Insulin-like growth factors (including IGF-1) relating to cancer, heart disease, muscle development and diabetes Insulin-like growth factor binding proteins Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Institution not known
Bachelor of Medicine Institution not known
Doctor of Philosophy Institution not known

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP)

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Characterisation of the structure and function of a novel membrane protein: a putative calcium transfer Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2003
Insulin-like growth factor binding proteins: structure and ligand interactions Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Determinants of insulin-like growth factor (IGF) binding and biological actions of IGF binding protein-6 Chief Investigator NHMRC Project Grants 01/01/2004
The role of ezrin-radixin-moesin proteins, novel binding proteins for advanced glycation endproducts, in diabetic nephropathy Chief Investigator JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL Regular Research Grants 01/01/2005

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2005

Journal Articles

  • A case of mucormycosis limited to the parotid gland.
    Year: 2005
    Journal: Head & Neck
    Volume: 27
    Issue: 12
    Page numbers: 1108-11011
    Author(s):
    URL - open access http://www3.interscience.wiley.com/cgi-bin/abstract/112130861/ABSTRACT
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  • Effects of advanced glycation end products on ezrin-dependent functions in LLC-PK1 proximal tubule cells
    Year: 2005
    Journal: Annals of The New York Academy of Sciences
    Volume: 1043
    Page numbers: 609-616
    Publisher: New York Academy of Sciences(New York)
    Author(s):
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  • Expression of the IGF system in normal and diabetic transgenic (mRen-2)27 Rat Eye
    Year: 2005
    Journal: Investigative Ophthalmology and Visual Science
    Volume: 46
    Issue: 8
    Page numbers: 2708-2715
    Author(s):
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  • IGF-binding proteins - the pieces are falling into place
    Year: 2005
    Journal: Trends in Endocrinology and Metabolism
    Volume: 16
    Issue: 5
    Page numbers: 228-234
    Publisher: Elsevier Science London(London)
    Author(s):
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  • Insulin-like growth factor binding protein-2 to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion
    Year: 2005
    Journal: Endocrinology
    Volume: 146
    Issue: 10
    Page numbers: 4445-4455
    Publisher: Endocrine Society(Maryland)
    Author(s):
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  • Localization of the Ezrin binding epitope for Glycated proteins
    Year: 2005
    Journal: Annals of The New York Academy of Sciences
    Volume: 1043
    Page numbers: 617-624
    Publisher: New York Academy of Sciences(New York)
    Author(s):
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Publications in 2004

Journal Articles

  • Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase c-α-dependent pathway
    Year: 2004
    Journal: Diabetes
    Volume: 53
    Page numbers: 2921-2930
    Publisher: American Diabetes Association(Virginia)
    Author(s):
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  • Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions
    Year: 2004
    Journal: FEBS Letters
    Volume: 568
    Page numbers: 19-22
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
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  • C-Termial domain of Insulin-like growth factor (IGF) binding protein-6: Structure and interaction with IGF-II
    Year: 2004
    Journal: Molecular Endocrinology
    Volume: 18
    Issue: 11
    Page numbers: 2740-2750
    Publisher: Endocrine Society(Philadelphia)
    Author(s):
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  • C-Terminal domain of insulin-like growth Factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Page numbers: 11187-11195
    Publisher: American Chemical Society(Washington DC)
    Author(s):
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  • Contributions of the N-and C-terminal domains of IGF binding protein-6 to IGF binding
    Year: 2004
    Journal: Journal of Molecular Endocrinology
    Volume: 33
    Page numbers: 377-386
    Publisher: Society for Endocrinology(Stokebristol)
    Author(s):
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  • Effect of an insulin-like growth factor binding protein fusion protein on Thymidine incorporation in Neuroblastoma and Rhabdomyosarcoma cell lines
    Year: 2004
    Journal: Endocrinology
    Volume: 145
    Issue: 7
    Page numbers: 3369-3374
    Publisher: Endocrine Society(Maryland)
    Author(s):
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  • Fibroblast growth factor-2 over-rides insulin-like growth factor-1 induced proliferation and cell survival in human neuroblastoma cells
    Year: 2004
    Journal: Journal of Cellular Physiology
    Volume: 199
    Page numbers: 371-380
    Publisher: Wiley-Liss(New York)
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  • Single and serial measurements of cardiac troponin I in asymptomatic patients on chronic hemodialysis
    Year: 2004
    Journal: Clinical Nephrology
    Volume: 61
    Issue: 1
    Page numbers: 40-46
    Publisher: Dustri-Verlag Dr. Karl Feistle
    Author(s):
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  • The insulin-like growth factor system: towards clinical applications
    Year: 2004
    Journal: Clinical Biochemist Reviews
    Volume: 25
    Issue: August
    Page numbers: 153-162
    Publisher: Australasian Association of Clinical Biochemists
    Author(s):
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Publications in 2003

Book Chapters

  • IGFBPs - gene and protein structure
    Year: 2003
    Book: Insulin-like Growth Factors
    Publisher: Kluwer Academic/Plenum Publishers(New York)
    Authors(s):

Journal Articles

  • Insulin-like Growth factor binding protein-6 and CCI-779, an Ester Analog of Rapamycin Additively Inhibit Rhabdmyosarcoma Growth
    Year: 2003
    Journal: Hormone and Metabolic Research
    Volume: 35
    Page numbers: 1-7
    Publisher: Georg Thieme Verlag(Stuttgart)
    Author(s):
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  • Letter to editor: 1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6)
    Year: 2003
    Journal: Journal of Biomolecular NMR
    Volume: 25
    Page numbers: 251-252
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
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  • The amino-terminal domains of the Ezrin, Radixin, and Moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: July 11
    Page numbers: 25783-25789
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
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  • Upregulation of cardiac insulin-like growth factor-I receptor by ACE inhibition after myocardial infarction: potential role in remodeling
    Year: 2003
    Journal: Journal of Histochemistry and Cytochemistry
    Volume: 51
    Issue: 6
    Page numbers: 831-839
    Publisher: Histochemical Society(Seattle)
    Author(s):
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  • Urokinase type plasminogen activator receptor is involved in Insulin-like growth factor-induced migration of rhabdomyosarcoma cells in vitro
    Year: 2003
    Journal: Journal of Cellular Physiology
    Volume: 197
    Issue: 1
    Page numbers: 131- 138
    Publisher: Wiley-Liss(New York)
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Publications in 2002

Journal Articles

  • Diabetic ketoacidosis secondary to dento-alveolar infection
    Year: 2002
    Journal: International Journal of Oral and Maxillofacial Surgery
    Volume: 31
    Issue: 1
    Page numbers: 57-59
    Publisher: Churchill Livingstone
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  • Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-1 administration
    Year: 2002
    Journal: American Journal of Pathology
    Volume: 161
    Issue: 6
    Page numbers: 2263-2272
    Publisher: American Society of Investigative Pathology Inc(Maryland)
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  • Inhibition of Caco-2 cell proliferation by All-trans retinoic acid: role of insulin-like growth factor binding protein-6
    Year: 2002
    Journal: Journal of Cellular Physiology
    Volume: 190
    Page numbers: 92-100
    Publisher: Wiley-Liss(New York)
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Publications in 2001

Journal Articles

  • Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
    Year: 2001
    Journal: Journal of Clinical Investigation
    Volume: 108
    Page numbers: 1853-1863
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced but not basal proliferation and adhesion of LIM 1215 colon cancer cells
    Year: 2001
    Journal: Molecular and Cellular Endocrinology
    Volume: 174
    Page numbers: 121-127
    Publisher: Elsevier Science Ireland(Coclare)
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  • Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo
    Year: 2001
    Journal: Carcinogenesis
    Volume: 22
    Issue: 10
    Page numbers: 1625-1631
    Publisher: Oxford University Press(Oxford)
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  • Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo
    Year: 2001
    Journal: International Journal of Cancer
    Volume: 94
    Page numbers: 645-651
    Publisher: Wiley-Liss(New York)
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