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PROF ANTONY BURGESS



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital
Position: Honorary (Professorial Fellow)
Email:
Homepage: www.ludwig.edu.au
Work: 9341 3116
Building: Med Research Building
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Membrane Biology Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne
Doctor of Philosophy University of Melbourne

Memberships

Membership Type Membership Body Description Start Date End Date
Member Asia-Pacific International Molecular Biology Network Fellow 01-Jan-1998
Member Victorian Breast Cancer Scientific Committee 01-Jan-2001
Member CSIRO P-Health Advisory Council 01-Jan-2003
Member VBCRC Board Member 01-Jan-2003
Member Bio21 Board Member 01-Jan-2003
Member Dept. of Human Services Ministerial Taskforce for Cancer Committee Member 01-Jan-2003
Member CSIRO P-Health Advisory Committee Chairperson 01-Jan-2004
Member Cancer Council Victoria Venture Grants Advisory Committee Chairperson 01-Jan-2006
Member Vanderbilt University Gastrointestinal Cancer SPORE Grant Committee 01-Jan-2006
Member Cancer Council Victoria Vic. Cancer Research Tissue Bank Consortium C'tee 01-Jan-2006

Honours

Honour Date Awarded
Companion of the Order of Australia

Fellowships

Fellowship Date Awarded
Fellow of the Australian Academy of Science (FAA) 01-Jan-1993

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal Gottschalk Medal, Aust. Academy of Science'1981 01-Jan-1981
Medal Centenary Medal 01-Jan-2003
Medal Leach Lecture Medal 01-Jan-2005
Other (Award) Australian Research Council Queen Elizabeth II Postdoctoral Research Fellowship 01-Jan-1975

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Identifying mitogenic signalling proteins with phosphatidyl inositol lipids Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
PRE-CLINICAL STUDY AND PHASE 1 TRIAL OF PI3-KINASE INHIBITORS IN THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA Chief Investigator VIC CANCER AGENCY Clinical Trials Pilot Study Grant 14/05/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • EGFR family: Structure physiology signalling and therapeutic targets.
    Year: 2008
    Journal: Growth Factors
    Volume: 26
    Issue: 5
    Page numbers: 263-274
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  • IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
    Year: 2008
    Journal: Blood
    Volume: 111
    Issue: 8
    Page numbers: 3978-3985
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  • Predominance of activated EGFR higher-order oliogmers on the cell surface.
    Year: 2008
    Journal: Growth Factors
    Volume: 26
    Issue: 6
    Page numbers: 316-324
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  • Recruitment of adenomatous polyposis coli and β-catenin to axin-puncta.
    Year: 2008
    Journal: Oncogene
    Volume: 27
    Page numbers: 5808-5820
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  • The PI(3,5)P2 and PI(4,5)P2 Interactomes
    Year: 2008
    Journal: Journal of Proteome Research
    Volume: 7
    Issue: 12
    Page numbers: 5295-5313
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Publications in 2007

Journal Articles

  • A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors.
    Year: 2007
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 104
    Issue: 10
    Page numbers: 4071-4076
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  • De novo design of β-helical polypeptides.
    Year: 2007
    Journal: Growth Factors
    Volume: 25
    Issue: 3
    Page numbers: 168-190
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  • Identification of a novel EGF-sensitive cell cycle checkpoint.
    Year: 2007
    Journal: Experimental Cell Research
    Volume: 313
    Issue: 3
    Page numbers: 511-526
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  • Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF.
    Year: 2007
    Journal: Journal of Leukocyte Biology
    Volume: 82
    Issue: 4
    Page numbers: 915-925
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  • Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis.
    Year: 2007
    Journal: Journal of Immunology
    Volume: 178
    Issue: 10
    Page numbers: 6435-6443
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  • The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor AG1478 Increases the Formation of Inactive Untethered EGFR Dimers

    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 5
    Page numbers: 2840-2850
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Publications in 2006

Journal Articles

  • Designing amino acid residues with single conformations.
    Year: 2006
    Journal: Protein Engineering Design & Selection
    Volume: 19
    Issue: 9
    Page numbers: 401-408
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  • In situ phosphorylation of immobilzed receptors on biosensor surfaces: Application to E- cadherin/ß-catenin interactions.
    Year: 2006
    Journal: Analytical Biochemistry
    Volume: 357
    Issue: 2
    Page numbers: 277-288
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  • Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine Kinase
    Year: 2006
    Journal: Biochemical Pharmacology
    Volume: 71
    Issue: 2006
    Page numbers: 1422-1434
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  • Purification and characterization of a high specificity polyclonal antibody to the adnomatous polyposis coli tumour suppressor protein.
    Year: 2006
    Journal: Biomedical Chromatography
    Volume: 20
    Issue: 6-7
    Page numbers: 569-575
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Publications in 2005

Journal Articles

  • A phase 1 trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 13
    Page numbers: 4810-4817
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  • Biosensor-based Micro-affinity Purification for the Proteomic Analysis of Protein Complexes.
    Year: 2005
    Journal: Journal of Proteome Research
    Volume: 4
    Issue: 5
    Page numbers: 1646-1656
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  • Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR
    Year: 2005
    Journal: British Journal of Cancer
    Volume: 92
    Issue: 6
    Page numbers: 1069-1077
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  • Enhanced Efficacy of Radioimmunotherapy with 90Y-CHX-A-DTPA-hu3S193 by Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling with EGFR Tyrosine Kinase Inhibitor AG1478
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 19 Suppl
    Page numbers: 7080 - 7086
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  • Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG1478-mesylate, with albumin
    Year: 2005
    Journal: Analytical Biochemistry
    Volume: 342
    Issue: 2
    Page numbers: 292-299
    Publisher: Academic Press - Elsevier Science(San Diego)
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  • Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 34
    Page numbers: 30392-30399
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  • Phase I Trial of 131I-huA33 in Patients with Advanced Colorectal Carcinoma
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 13
    Page numbers: 4818-4826
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  • The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor
    Year: 2005
    Journal: FASEB Journal
    Volume: 19
    Issue: 7
    Page numbers: 780-782
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  • The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF)
    Year: 2005
    Journal: Growth Factors
    Volume: 23
    Issue: 2
    Page numbers: 97-110
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  • Treatment of Human Tumour Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor - Specific Antibody Generates Enhanced Antitumour Activity.
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Issue: 17
    Page numbers: 6390 - 6399
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  • Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical Epidermal Growth Factor Receptor - specific antibody generates enhanced antitumor activity.
    Year: 2005
    Journal: Clinical Cancer Research
    Volume: 11
    Page numbers: 6390-6399
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Publications in 2004

Journal Articles

  • CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 21
    Page numbers: 22387-22398
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 29
    Page numbers: 30375-30384
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  • Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.
    Year: 2004
    Journal: Journal of Cell Science
    Volume: 3
    Issue: 117
    Page numbers: 427-439
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  • The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR
    Year: 2004
    Journal: Oncogene
    Volume: 23
    Issue: 36
    Page numbers: 6095-6104
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Publications in 2003

Journal Articles

  • Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.


    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 26
    Page numbers: 15871-15876
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  • An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors.
    Year: 2003
    Journal: Molecular Cell
    Volume: 12
    Issue: 3
    Page numbers: 541-552
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  • Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand
    Year: 2003
    Journal: Growth Factors
    Volume: 21
    Issue: 1
    Page numbers: 15-30
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  • Epidermal growth factor receptor: mechanisms of activation and signalling. Experimental cell research
    Year: 2003
    Journal: Experimental Cell Research
    Volume: 284
    Page numbers: 31-53
    Publisher: Academic Press(California)
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  • The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
    Year: 2003
    Journal: Molecular Cell
    Volume: 11
    Issue: 2
    Page numbers: 495-505
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Publications in 2002

Journal Articles

  • A novel monoclonal antibody specific for the De2-7 EGFR that also recognises the EGFRexpressed in cells containing amplification of the EGFR gene.


    Year: 2002
    Journal: International Journal of Cancer
    Volume: 98
    Page numbers: 398-404
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  • Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
    Year: 2002
    Journal: Cell
    Volume: 110
    Issue: 6
    Page numbers: 763-773
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  • Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 1102-1109
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  • Modeling the epidermal growth factor - epidermal growth factor receptor L2 domain interaction: implications for the ligand binding process.
    Year: 2002
    Journal: Journal of Biomolecular Structure and Dynamics
    Volume: 6
    Issue: 961-972
    Page numbers: 19
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  • Rapid microscale enzymic semisynthesis of epidermal growth factor (EGF) analogues
    Year: 2002
    Journal: Growth Factors
    Volume: 20
    Issue: 2
    Page numbers: 71-80
    Publisher: Harwood Academic Publishing GMBH(Reading)
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  • The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively blocks the growth of RAS transformants.
    Year: 2002
    Journal: Cancer
    Volume: 8
    Issue: 4
    Page numbers: 328-36
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Publications in 2001

Journal Articles

  • Conformational analysis of thiopeptides: (phi,psi) maps of thio-substituted dipeptides. Journal of computational chemistry.


    Year: 2001
    Journal: Journal of Computational Chemistry
    Volume: 22
    Issue: 10
    Page numbers: 1026-1037
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  • Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm.


    Year: 2001
    Journal: Protein Engineering
    Volume: 14
    Issue: 1
    Page numbers: 39-45
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  • Conformational analysis of thiopeptides: derivation of Sp(2) sulfur parameters for the CFF91 force field
    Year: 2001
    Journal: Journal of Computational Chemistry
    Volume: 22
    Page numbers: 1010-1025
    Publisher: John Wiley & Sons(New York)
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  • Conformational analysis of thiopeptides: free energy calculations on the effects of thio-substitutions on the conformational distributions of alanine dipeptides.
    Year: 2001
    Journal: Journal of Molecular Graphics and Modelling
    Volume: 20
    Issue: 3
    Page numbers: 245-256
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  • Design of Ras-Raf interaction using a computational combinatorial algorithm
    Year: 2001
    Journal: Protein Engineering
    Volume: 14
    Page numbers: 39-45
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  • High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
    Year: 2001
    Journal: Journal of Chromatography B: Biomedical Sciences and Applications
    Volume: 754
    Page numbers: 193-199
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  • Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitizized to cisplatin by the AG1478 tyrosine kinase inhibitor
    Year: 2001
    Journal: Journal of Neurosurgery
    Volume: 95
    Page numbers: 472-479
    Publisher: American Association of Neurological Surgeons(Virginia)
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  • Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins
    Year: 2001
    Journal: Experimental Cell Research
    Volume: 266
    Page numbers: 1-10
    Publisher: Academic Press(California)
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  • Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR
    Year: 2001
    Journal: Cancer Research
    Volume: 61
    Page numbers: 5355-5361
    Publisher: American Association for Cancer Research(Alabama)
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  • Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 26741-26744
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  • Regulation of Transforming Growth Factor-β Signaling.
    Year: 2001
    Journal: Molecular Cell Biology Research Communications
    Volume: 4
    Issue: 2001
    Page numbers: 321-330
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  • Specific localization, gamma camera imaging, and intracellular trafficking of radiolabelled chimeric anti-GD3 ganglioside monoclonal antibody KM871 in SK-MEL-28 melanoma xenografts
    Year: 2001
    Journal: Cancer Research
    Volume: 61
    Page numbers: 4474-4482
    Publisher: American Association for Cancer Research(Alabama)
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  • Specific targeting, biodistribution, and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma: results of a phase I trial
    Year: 2001
    Journal: Journal of Clinical Oncology
    Volume: 19
    Issue: 19
    Page numbers: 3976-3987
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes.
    Year: 2001
    Journal: Journal of Peptide Research
    Volume: 58
    Page numbers: 204-212
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Synthesis,X-ray crystallographic structures of thio substituted N-acetyl N'-methylamide alanine and evaluation of sp2 sulfur parameters of the CFF91 force field
    Year: 2001
    Journal: Journal of Peptide Research
    Volume: 58
    Issue: 1
    Page numbers: 67-78
    Publisher: Munksgaard International Publishers(Copenhagen)
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Conference Publications/Papers

  • The use of a synthetic biotinylaged peptide probe for the isolation of adenoatous polyposis coli (APC) tumur suppressor protein complexes.
    Year: 2001
    Event name: 2nd International and 17th American Peptide Symposium.
    Conference Publication: Peptides. The Wave of the Future.
    Page numbers: 998-999
    Publisher: American Peptide Society(San Diego)
    Author(s):
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