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A/PROF MARC ACHEN



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital
Position: Honorary (Principal Fellow)
Email:
Homepage: http://www.ludwig.edu.au/intranet/
Work: 03 93413155
Building: Med Research Building
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Cancer Australia

International Linkages

Country Establishment Collaboration
Finland University of Helsinki Exchange, Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosphy University of Melbourne 31-Dec-1989
Bachelor of Science Honours University of Melbourne 31-Dec-1983

Memberships

Membership Type Membership Body Description Start Date End Date
Member National Health and Medical Research Council Senior Research Fellowship 01-Jan-2004

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal Ludwig Institute for Cancer Research 15-Oct-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Sox18 induces development of the lymphatic vasculature in mice.


    Year: 2008
    Journal: Nature
    Volume: 456
    Issue: 7222
    Page numbers: 643-647
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  • Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D is not equivalent to VEGF Receptor 3 Deletion in Mouse Embryos.
    Year: 2008
    Journal: Molecular and Cellular Biology
    Volume: 28
    Issue: 15
    Page numbers: 4843-50
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  • From Anit-angiogenesis to Anti-Lymphangiogenesis: Emerging Trends in Cancer Therapy.
    Year: 2008
    Journal: Lymphatic Research and Biology
    Volume: 6
    Issue: (3-4)
    Page numbers: 165-72
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  • Molecular control of lymphatic metastasis.
    Year: 2008
    Journal: Annals of The New York Academy of Sciences
    Volume: 1131
    Page numbers: 225-234
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Publications in 2007

Journal Articles

  • A system for quantifying the patterning of the lymphatic vasculature.
    Year: 2007
    Journal: Growth Factors
    Volume: 25
    Issue: 6
    Page numbers: 417-25
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  • Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.
    Year: 2007
    Journal: American Journal of Pathology
    Volume: 170
    Issue: 4
    Page numbers: 1348-1361
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  • Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
    Year: 2007
    Journal: FASEB Journal
    Volume: 21
    Issue: 2007
    Page numbers: 1088-1098
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Conference Publications/Papers

  • Molecular pathways for the lymphangiogenesis and their role in human disease.
    Year: 2007
    Event name: Novartis Foundation Symposium 281
    Conference Publication: Decoding the genomic control of immune reactions
    Volume: 281
    Issue: 2007
    Page numbers: 38-43
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Author(s):

Publications in 2006

Journal Articles

  • Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphtic vessel maturation.


    Year: 2006
    Journal: American Journal of Pathology
    Volume: 169
    Issue: 2
    Page numbers: 708-718
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  • Current strategies for modulating lymphangiogenesis signalling pathways in human disease.
    Year: 2006
    Journal: Current Medicinal Chemistry
    Volume: 13
    Issue: 7
    Page numbers: 783-792
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  • Lymphatic vessels in cancer metastasis: bridging the gaps.
    Year: 2006
    Journal: Carcinogenesis
    Volume: 27
    Issue: 9
    Page numbers: 1729-1738
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  • Targeting lymphangiogenesis to prevent tumour metastasis.
    Year: 2006
    Journal: British Journal of Cancer
    Volume: 94
    Issue: 10
    Page numbers: 1355-1360
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  • Tumor lymphangiogenesis and metastatic spread - new players begin to emerge.
    Year: 2006
    Journal: International Journal of Cancer
    Volume: 119
    Page numbers: 1755-1760
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Publications in 2005

Journal Articles

  • Focus on lymphangiogenesis in tumor metastasis
    Year: 2005
    Journal: Cancer Cell
    Volume: 7
    Page numbers: 121-127
    Publisher: Cell Press(Philadelphia)
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  • Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism
    Year: 2005
    Journal: Gene Therapy
    Volume: 12
    Page numbers: 980-987
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  • Lymphatic endothelium: An important interactive surface for malignant cells
    Year: 2005
    Journal: Pulmonary Pharmacology and Therapeutics
    Volume: 19
    Page numbers: 51-60
    Publisher: Academic Press(London)
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  • Mechanisms of lymphangiogenesis: Targets for blocking the metastatic spread of cancer
    Year: 2005
    Journal: Current Cancer Drug Targets
    Volume: 8
    Issue: 5
    Page numbers: 561-71
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  • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation Journal of Clinical Investigation
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Issue: 2
    Page numbers: 247-257
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  • Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
    Year: 2005
    Journal: International Journal of Oncology
    Volume: 27
    Issue: 3
    Page numbers: 669-679
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  • Vascular endothelial growth factor-D is dispensible for development of the lymphatic system
    Year: 2005
    Journal: Molecular and Cellular Biology
    Volume: 25
    Issue: 6
    Page numbers: 2441-2449
    Publisher: American Society for Microbiology(Washington DC)
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Publications in 2004

Journal Articles

  • Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart
    Year: 2004
    Journal: Circulation
    Volume: 109
    Issue: 8
    Page numbers: 1029-1035
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  • Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer
    Year: 2004
    Journal: Clinical Cancer Research
    Volume: 10
    Issue: 15
    Page numbers: 5137-5144
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  • Molecular regulation of the VEGF-family - inducers of angiogenesis and lymphangiogenesis
    Year: 2004
    Journal: APMIS
    Volume: 112
    Page numbers: 463-480
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  • Molecular targeting of lymphatics for therapy
    Year: 2004
    Journal: Current Pharmaceutical Design
    Volume: 10
    Page numbers: 65-74
    Publisher: Bentham Science Publishers(Sharjah)
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Publications in 2003

Journal Articles

  • VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.


    Year: 2003
    Journal: Circulation Research
    Volume: 92
    Page numbers: 1098-1106
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  • Angiogenic responses of vascular endothelial growth factors in periadventitial tissue
    Year: 2003
    Journal: Human Gene Therapy
    Volume: 14
    Issue: 15
    Page numbers: 1451-1462
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  • Plasmin activates the lymphangiongenic growth factors VEGF-C and VEGF-D
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 6
    Page numbers: 863-868
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  • Regenerating lizard tails: a new model for investigating lymphangiogenesis
    Year: 2003
    Journal: FASEB Journal
    Volume: 17
    Issue: 3
    Page numbers: 479-481
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  • Vascular endothelial growth factor-D expression in human atherosclerotic lesions
    Year: 2003
    Journal: Cardiovascular Research
    Volume: 59
    Page numbers: 971-979
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  • Viral Vascular Endothelial Growth Factors Vary Extensively in Amino Acid Sequence, Receptor-binding Specificities, and the Ability to Induce Vascular Permeability yet Are Uniformly Active Mitogens
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 39
    Page numbers: 38004-38014
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Publications in 2002

Journal Articles

  • Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo
    Year: 2002
    Journal: Blood
    Volume: 99
    Page numbers: 4434-4442
    Publisher: American Society of Hematology(Washington DC)
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  • Lymphangiogenesis and cancer metastasis
    Year: 2002
    Journal: Nature Reviews Cancer
    Volume: 2
    Issue: 16
    Page numbers: 573-583
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  • Molecular control of lymphangiogenesis
    Year: 2002
    Journal: Bioessays
    Volume: 24
    Page numbers: 1030-1040
    Publisher: Company of Biologists(Cambridge)
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  • The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer
    Year: 2002
    Journal: Growth Factors
    Volume: 20
    Page numbers: 99-107
    Publisher: Harwood Academic Publishing GMBH(Reading)
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  • The role of tumor lymphangiogenesis in metastatic spread
    Year: 2002
    Journal: FASEB Journal
    Volume: 16
    Page numbers: 922-934
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2001

Journal Articles

  • Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C receptor VEGFR-3
    Year: 2001
    Journal: EMBO Journal
    Volume: 20
    Page numbers: 4762-4773
    Publisher: Oxford University Press(Oxford)
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  • Localization of vascular endothelial growth factor-D in malignant melanoma suggests a role in tumour angiogenesis
    Year: 2001
    Journal: Journal of Pathology
    Volume: 193
    Page numbers: 147-154
    Publisher: John Wiley & Sons(West Sussex)
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  • Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 44307-44314
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    Year: 2001
    Journal: EMBO Journal
    Volume: 20
    Page numbers: 1223-1231
    Publisher: Oxford University Press(Oxford)
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  • The specificity of receptor binding by vascular endothelial growth factor-D is different in mouse and man
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 19166-19171
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • VEGF-D is an x-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme
    Year: 2001
    Journal: Molecular Medicine
    Volume: 7
    Page numbers: 598-608
    Publisher: Oxford University Press(Oxford)
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  • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    Year: 2001
    Journal: Nature Medicine
    Volume: 7
    Page numbers: 186-191
    Publisher: Nature America(New York)
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