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PROF THOMAS KAY



Contact Details

Organization: Medicine - St Vincent's Hospital
Position: Honorary (Professorial Fellow)
Email:
Homepage: www.medstv.unimelb.edu.au
Work: 03 9288 2481
Building: SVIMR
Campus: St Vincents Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Autoimmunity Australia
Immunopathogenesis of Type 1 diabetes mellitus and animal models of TIDM Australia
Role of cytotoxic T cells and cytokines in the initiation and progression of autoimmune diabetes and in -cell destruction Australia
Regulation of MHC gene expression Australia
Clinical immunology Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medical Science University of Melbourne 31-Dec-1978
Bachelor of Medicine & Bachelor of Surgery University of Melbourne 31-Dec-1980
Master of Medicine Institution not known
Doctor of Philosophy University of Melbourne 31-Dec-1989

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 31-Dec-1987
Fellow of the Royal College of Pathologists, Australia (FRCPA) 31-Dec-1993

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship National Heart Foundation Vacation Scholarship 31-Dec-1975
Prize Australian Medical Association Prize 31-Dec-1980
Scholarship The University of Melbourne Keith Levi Memorial Scholarship for Medicine 31-Dec-1980
Prize The University of Melbourne Robert Gartly Healy Prize in Medicine 31-Dec-1980
Prize The University of Melbourne Grieve Memorial Prize in Paediatrics 31-Dec-1980
Scholarship The University of Melbourne Beaney Scholarship in Surgery 31-Dec-1980
Prize The University of Melbourne Robert Gartly Healy Prize in Surgery 31-Dec-1980
Prize The University of Melbourne Ryan Prize in Medicine 31-Dec-1980
Prize The University of Melbourne Ryan Prize in Surgery 31-Dec-1980
Other (Award) Anti-Cancer Council of Victoria Postgraduate Medical Fellowship 31-Dec-1986
Other (Award) Royal Australasian College of Physicians Bushell Fellowship 31-Dec-1989
Other (Award) National Health and Medical Research Council Neil Hamilton Fairley Fellowship 31-Dec-1989
Other (Award) Endocrine Society (USA) New Investigator Award 31-Dec-1991
Other (Award) Royal Australasian College of Physicians Golden Jubilee Fellowship 31-Dec-1992
Other (Award) Viertel Foundation Clinical Investigator Award 31-Dec-1995
Other (Award) Juvenile Diabetes Foundation Career Development Award 31-Dec-1997

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
IMPROVEMENT IN HEPATIC INSULIN SENSITIVITY IN LIVER SPECIFIC SOCS KNOCKOUT MICE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
INSULIN RESISTANCE AND VASCULAR RISK FACTORS IN ISLET TRANSPLANT SURVIVAL. Chief Investigator JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL Islet Transplation Program 30/06/2006
CELL DEATH PATHWAYS AND TYPE 1 DIABETES Chief Investigator NHMRC NHMRC/JDRF Special Program Grants in Type 1 Diabetes 01/01/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Book Chapters

  • Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice
    Year: 2008
    Book: Defining Optimal Immunotherapies For Type 1 Diabetes
    Publisher: John Wiley & Sons(Chichester)
    Authors(s):
    Editors(s):

Journal Articles

  • Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells


    Year: 2008
    Journal: Diabetes
    Volume: 57
    Page numbers: 1284-92
    Author(s):
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  • Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice
    Year: 2008
    Journal: Journal of Immunology
    Volume: 180
    Page numbers: 4458-4464
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  • Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro
    Year: 2008
    Journal: Human Immunology
    Volume: 69
    Page numbers: 543-551
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  • Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3
    Year: 2008
    Journal: Molecular Immunology
    Volume: 45
    Page numbers: 2888-2896
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  • Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis
    Year: 2008
    Journal: Journal of Virology
    Volume: 82
    Issue: 13
    Page numbers: 6139-6149
    Author(s):
    URL - restricted access http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18417562
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Publications in 2007

Journal Articles

  • Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets
    Year: 2007
    Journal: Xenotransplantation
    Volume: 14
    Issue: 2
    Page numbers: 119-25
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Publications in 2006

Journal Articles

  • Responses against islet antigens in NOD mice prevented by tolerance to proinsulin but not IGRP


    Year: 2006
    Journal: Journal of Clinical Investigation
    Volume: 116
    Issue: 12
    Page numbers: 3258-3264
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  • A critical role for Granzyme B, in addition to perforin and TNFα, in alloreactive CTL-induced mouse pancreatic beta cell death
    Year: 2006
    Journal: Transplantation
    Volume: 81
    Issue: 2
    Page numbers: 146-54
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  • Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy β-cells via the perforin and Fas pathways
    Year: 2006
    Journal: Diabetes
    Volume: 55
    Issue: 9
    Page numbers: 2412-8
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  • Granzyme B-mediated death of pancreatic β-Cells requires the proapoptotic BH3-only molecule bid
    Year: 2006
    Journal: Diabetes
    Volume: 55
    Issue: 8
    Page numbers: 2212-9
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  • IL-1β breaks tolerance through expansion of CD25+ effector T cells1
    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Issue: 12
    Page numbers: 7278-87
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  • Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL
    Year: 2006
    Journal: International Immunology
    Volume: 18
    Issue: 6
    Page numbers: 837-46
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  • Perturbations in nuclear factor-κB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Issue: 1
    Page numbers: 20-7
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  • Prolonged local expression of anti-CD4 antibody by adenovirally transduced allografts can promote long-term graft survival
    Year: 2006
    Journal: Journal of Gene Medicine
    Volume: 8
    Page numbers: 42-52
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  • SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes 
    Year: 2006
    Journal: Journal of Autoimmunity
    Volume: 27
    Issue: 3
    Page numbers: 166-73
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  • Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Year: 2006
    Journal: Cell Metabolism
    Volume: 4
    Issue: 6
    Page numbers: 465-74
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Publications in 2005

Journal Articles

  • Socs 1 deficiency enhances hepatic insulin signaling
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 31516-31521
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation
    Year: 2005
    Journal: Blood
    Volume: 106
    Page numbers: 1668-1675
    Publisher: American Society of Hematology(Washington DC)
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  • The insulin A-chain epitope recognized by human T cells is posttranslationally modified
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1191-1197
    Publisher: Rockefeller University Press(New York)
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  • Transgenic Expression of Dominant-Negative Fas-Associated Death Domain Protein in β Cells Protects against Fas Ligand-Induced Apoptosis and Reduces Spontaneous Diabetes in Nonobese Diabetic Mice1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 293-301
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2004

Journal Articles

  • Bcl-2 Protection of islet allografts is unmasked by costimulation blockade
    Year: 2004
    Journal: Transplantation
    Volume: 77
    Issue: 10
    Page numbers: 1610-1623
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
    Year: 2004
    Journal: Diabetes
    Volume: 53
    Page numbers: 113-121
    Publisher: American Diabetes Association(Virginia)
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  • Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency
    Year: 2004
    Journal: American Journal of Pathology
    Volume: 165
    Issue: 3
    Page numbers: 913-921
    Publisher: American Society of Investigative Pathology Inc(Maryland)
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  • Suppressor of Cytokine Signaling-1 Overexpression Protects Pancreatic β Cells from CD8+ T Cell-Mediated Autoimmune Destruction1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 5714-5721
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2003

Journal Articles

  • Activated macrophages require T cells for xenograft rejection under the kidney capsule
    Year: 2003
    Journal: Immunology and Cell Biology
    Volume: 81
    Page numbers: 451-458
    Publisher: Blackwell Science Asia(Carlton)
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  • Fas is detectable on β cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 6292-6297
    Publisher: American Association of Immunologists(Maryland)
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  • Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    Year: 2003
    Journal: Immunity
    Volume: 18
    Page numbers: 475-487
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  • Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γc-dependent cytokines in peripheral T cells
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 25
    Page numbers: 22755-22761
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • Comparison of insulin secretory function in two mouse models with different susceptibility to beta cell failure
    Year: 2002
    Journal: Endocrinology
    Volume: 143
    Page numbers: 2085-2092
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  • Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Issue: 589-604
    Page numbers: 5
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  • Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production
    Year: 2002
    Journal: Diabetes
    Volume: 51
    Page numbers: 311-316
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  • Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 27945-27952
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  • Transmembrane TNF and IFN gamma induce caspase-independent death of primary mouse pancreatic beta cells
    Year: 2002
    Journal: Autoimmunity
    Volume: 35
    Issue: 6
    Page numbers: 369-75
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Publications in 2001

Journal Articles

  • Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis
    Year: 2001
    Journal: Journal of Experimental Medicine
    Volume: 194
    Page numbers: 873-881
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  • International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
    Year: 2001
    Journal: Diabetes
    Volume: 50
    Issue: 11
    Page numbers: 2451-8
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  • gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1
    Year: 2001
    Journal: Diabetes
    Volume: 50
    Issue: 12
    Page numbers: 2744-51
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