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A/PROF MATTHEW GILLESPIE



Contact Details

Organization: Medicine - St Vincent's Hospital
Position: Honorary (Principal Fellow)
Homepage: www.medstv.unimelb.edu.au
Work: 03 9288 2480
Mobile: 0400 593 310
Fax: 03 9416 2676
Level: 03
Building: SVIMR
Campus: St Vincents Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Parathyroid hormone-related protein (PTHrP). Breast cancer Australia
Breast cancer metastases to bone. Australia
Osteoclast activation and inhibition. Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 31-Dec-1981
Doctor of Philosophy Monash University 31-Dec-1986

Memberships

Membership Type Membership Body Description Start Date End Date
Member American Society for Bone and Mineral Research Member 31-Dec-2005
Member Australian and New Zealand Bone and Mineral Society Member 31-Dec-2005
Member Australian Society for Medical Research Member 31-Dec-2005
Member European Calcified Tissue Society Member 31-Dec-2005
Member International Bone and Mineral Society Member 31-Dec-2005

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) National Health and Medical Research Council Australian Post-Doctoral Research Fellowship 31-Dec-1988
Other (Award) McGauran Trust McGauran Research Fellow 31-Dec-1992
Other (Award) National Health and Medical Research Council R.D. Wright Fellowship 31-Dec-1992
Other (Award) The International Bone and Calcium Institute Outstanding Investigator Award in the Bone Field 31-Dec-1997

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts


    Year: 2008
    Journal: Journal of Bone & Mineral Research
    Volume: 23
    Issue: 8
    Page numbers: 1170-81
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  • Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo


    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 45
    Page numbers: 30850-60
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  • Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling
    Year: 2008
    Journal: Journal of Bone & Mineral Research
    Volume: 23
    Issue: 12
    Page numbers: 2025-32
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  • IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Issue: 8
    Page numbers: 5720-9
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Publications in 2007

Journal Articles

  • Impact of cytokines and T lymphocytes upon osteoclast differentiation and function
    Year: 2007
    Journal: Arthritis Research & Therapy
    Volume: 9
    Issue: 2
    Page numbers: 103
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  • Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro
    Year: 2007
    Journal: Bone
    Volume: 40
    Issue: 2
    Page numbers: 305-15
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Publications in 2006

Journal Articles

  • Bone marrow-derived cells - fertilizer necessary for the seed and soil
    Year: 2006
    Journal: BoneKEy - Osteovision
    Volume: 3
    Issue: 4
    Page numbers: 16-18
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  • Inflammation-induced bone loss: can it be prevented?
    Year: 2006
    Journal: Rheumatic Disease Clinics of North America
    Volume: 32
    Issue: 4
    Page numbers: 759-73
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  • Mechanisms involved in skeletal anabolic therapies
    Year: 2006
    Journal: Annals of The New York Academy of Sciences
    Volume: 1068
    Page numbers: 458-470
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  • Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically
    Year: 2006
    Journal: Cancer Research
    Volume: 66
    Issue: 7
    Page numbers: 3620-8
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Publications in 2005

Journal Articles

  • Effects of Parathyroid Hormone on Wnt Signaling Pathway in Bone
    Year: 2005
    Journal: Journal of Cellular Biochemistry
    Volume: 95
    Page numbers: 1178-1190
    Publisher: Wiley-Liss(New York)
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  • Interleukin-11 receptor signaling is required for normal bone remodeling
    Year: 2005
    Journal: Journal of Bone & Mineral Research
    Volume: 20
    Issue: 7
    Page numbers: 1093-1102
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  • Modulation of osteoclast formation
    Year: 2005
    Journal: Biochemical and Biophysical Research Communications
    Volume: 328
    Issue: 3
    Page numbers: 739-745
    Publisher: Academic Press(California)
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  • The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line
    Year: 2005
    Journal: Cancer Research
    Volume: 65
    Issue: 11
    Page numbers: 4929-4938
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Publications in 2004

Journal Articles

  • Characterization of sugar binding by osteoclast inhibitory lectin
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 28
    Page numbers: 29043-29049
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways
    Year: 2004
    Journal: Journal of Clinical Investigation
    Volume: 113
    Issue: 3
    Page numbers: 379-389
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  • Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Page numbers: 89-99
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  • Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation
    Year: 2004
    Journal: British Journal of Haematology
    Volume: 126
    Page numbers: 192-201
    Publisher: Blackwell Science(Oxford)
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  • Osteopenia in Siah 1a mutant mice
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 28
    Page numbers: 29583-29588
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation
    Year: 2004
    Journal: Journal of Bone & Mineral Research
    Volume: 19
    Issue: 11
    Page numbers: 1873-1881
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  • Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis
    Year: 2004
    Journal: Arthritis and Rheumatism
    Volume: 50
    Issue: 7
    Page numbers: 2338-2346
    Publisher: Wiley-Liss(New York)
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Publications in 2003

Journal Articles

  • Differentiation potential of a mouse bone marrow stromal cell line
    Year: 2003
    Journal: Journal of Cellular Biochemistry
    Volume: 90
    Page numbers: 158-169
    Publisher: Wiley-Liss(New York)
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  • Generation and analysis of Siah2 mutant mice
    Year: 2003
    Journal: Molecular and Cellular Biology
    Volume: 23
    Issue: Dec 2003
    Page numbers: 9150-9161
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  • Interleukin-18 is a novel mitogen of osteogenic and chondrogenic cells
    Year: 2003
    Journal: Endocrinology
    Volume: 144
    Issue: 4
    Page numbers: 1194-1201
    Publisher: Endocrine Society(Maryland)
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  • Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles
    Year: 2003
    Journal: Vitamins and Hormones
    Volume: 66
    Page numbers: 345-384
    Publisher: Academic Press
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  • T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis
    Year: 2003
    Journal: Journal of Bone & Mineral Research
    Volume: 18
    Page numbers: 984-992
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Publications in 2002

Journal Articles

  • Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis
    Year: 2002
    Journal: Bone
    Volume: 30
    Issue: 2
    Page numbers: 340-346
    Publisher: Elsevier Science(New York)
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  • Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules
    Year: 2002
    Journal: Molecular Endocrinology
    Volume: 16
    Issue: 2
    Page numbers: 390-401
    Publisher: Endocrine Society(Philadelphia)
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  • Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 50
    Page numbers: 48808-48815
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis
    Year: 2002
    Journal: American Journal of Pathology
    Volume: 161
    Issue: 4
    Page numbers: 1419-1427
    Publisher: American Society of Investigative Pathology Inc(Maryland)
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  • The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with β-arrestin 1B
    Year: 2002
    Journal: FEBS Letters
    Volume: 527
    Page numbers: 71-75
    Publisher: Elsevier Science(Amsterdam)
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