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PROF GRAHAM BROWN



Contact Details

Organization: Nossal Institute for Global Health
Position: FOUNDATION DIRECTOR -NOSSAL INSTITUTE
Email:
Homepage: http://www.ni.unimelb.edu.au
Work: 8344 1999
Fax: 9347 6872
Level: 05
Building: Alan Gilbert Building
Campus: Parkville

Biography

Graham V Brown, MB BS(Melb), FRACP, MPH(Harvard), PhD(Melb), FAFPHM. FACTM

Formerly the James Stewart Professor of Medicine at the University of Melbourne and Head of the Department of Medicine (Royal Melbourne Hospital/Western Hospital), Graham Brown is Foundation Director of the Nossal Institute for Global Health, a new initiative of the University of Melbourne that aims to improve global health through research, evaluation, education, advocacy, development assistance and development of future leaders.

Professor Bown worked in Tanzania and Papua New Guinea before commencing a research career studying immunity to malaria, ending as Head of the Divison of Infection and Immunity at The Walter and Eliza Hall Institute of Medical Research. Following the closure of Fairfield Hospital, he created the  Victorian Infectious Diseases Service at the Royal Melbourne Hospital, stepping down as Head in 2006. He was Head of the Department of Medicine (RMH/WH) at the University of Melbourne from 1999 to 2007.  In addition to his clinical expertise in tropical medicine and infectious diseases, Professor Brown undertakes basic research in immunopathology of malaria and is an investigator on a research program devoted to mathematical modelling of infectious diseases. He has other interests in surveillance of infectious diseases and use of low cost technology for health. He is author or co-author of 210 publications. He is currently Chair of the Malaria Vaccine Advisory Committee of the World Health organization and the Scientific Consultants Group of the USAID Malaria Vaccine Development Program.

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Cell biology of malaria Australia
Cytoadherence and antigenic variation of Plasmodium falciparum Papua New Guinea, Australia
Mathematical modelling of infectious diseases Australia
Malaria vaccine development Papua New Guinea
Field studies of acquisition of immunity to malaria Papua New Guinea, Australia
Clinical infectious diseases Australia
Global health India, Mozambique

International Linkages

Country Establishment Collaboration
Indonesia The Eijkman Institute for Molecular Biology Exchange, Research, Teaching, Technical Assistance/Training
Papua New Guinea Papua New Guinea's Institute of Medical Research Exchange, Research, Teaching, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine University of Melbourne
Bachelor of Surgery University of Melbourne
Master of Public Health Harvard University
Doctor of Philosophy University of Melbourne

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 31-Dec-1970
Fellow of the Australian Faculty of Public Health Medicine (FAFPHM) 31-Dec-1983
Fellow of the Australasian College of Tropical Medicine (FACTM) 31-Dec-1983

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize University of Melbourne Stirling Prize for Surgery 23-Nov-1970
Other (Award) Royal Melbourne Hospital Wall Award for Junior RMO 31-Dec-1971
Other (Award) Australian Academy of Science/Australian Academy of Technological Sciences/Royal Society Australian Academy of Science/Australian Academy of Technological Sciences/Royal Society Exchange Programme 31-Dec-1990
Prize Royal Australasian College of Physicians The Eric Susman Prize 31-Dec-1992
Other (Award) Rotary Club of Melbourne-Latrobe Inc Inaugural Royce Abbey Oration 10-Jul-2001
Other (Award) Australasian Society of Infectious Diseases Presidential Oration 06-Apr-2005
Other (Award) Department of Human Services Innovation in Information Technology, Victorian Public Healthcare Award 14-Nov-2006
Other (Award) Melbourne Health Chairmans Award of Melbourne Health Outstanding leadership and excellence in their chosen field 11-Dec-2007
Other (Award) Australasian College of Tropical Medicine Ashdown Oration 12-Feb-2008
Other (Award) Queensland Institute of Medical Research Fellowship 14-Oct-2008

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
MECHANISMS OF MALARIA PARASITE ADHESION Chief Investigator NHMRC Project Grants 01/01/2001
Centre for Clinical Research Excellence in Infectious Diseases Chief Investigator NHMRC Centres of Clinical Research Excellence (CCRE) 01/01/2003
HOST PARASITE INTERACTIONS Chief Investigator WALTER & ELIZA HALL INST Project Grants (NHMRC) 01/01/2006
Molecular, spatial and mathematical techniques in the analysis of the epidemiology of tropical infectious diseases Principal Supervisor NHMRC Health Professional Research Training Fellowships 01/01/2006
Infection Control and post-discharge surveillance of surgical site infections Principal Supervisor NHMRC Medical & Dental Postgraduate Scholarships 01/01/2006
LIVE CELL IMAGING - INFLAMMATION, BRAINS, CANCER AND MALARIA MULTIFUNCTIONAL IMAGING FACILITY Chief Investigator THE IAN POTTER FOUNDATION Project Grants 04/04/2007
Malaria in Pregnancy: Project Major Activity 7 Chief Investigator LIVERPOOL SCHOOL OF TROPICAL MEDICINE Global Health Program (GATES FOUNDATION) 01/12/2007
Transcriptional control of antigenic variation in the malaria parasite Plasmodium falciparum Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate
    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 389
    Page numbers: 453-469
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  • Hospitalized community-acquired pneumonia in the elderly: an Australian case-cohort study
    Year: 2009
    Journal: Epidemiology and Infection
    Volume: 137
    Issue: 2
    Page numbers: 194-202
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Publications in 2008

Journal Articles

  • Empiric antibiotic prescribing for patients with community-acquired pneumonia: where can we improve?


    Year: 2008
    Journal: Internal Medicine Journal
    Volume: 38
    Page numbers: 174-177
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  • ICD-10 codes are a valid tool for identification of pneumonia in hospitalized patients aged ≥65 years


    Year: 2008
    Journal: Epidemiology and Infection
    Volume: 136
    Issue: 2
    Page numbers: 232-240
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  • Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
    Year: 2008
    Volume: 7
    Issue: 1
    Page numbers: 51
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  • Electronic antibiotic stewardship--reduced consumption of broad-spectrum antibiotics using a computerized antimicrobial approval system in a hospital setting
    Year: 2008
    Journal: Journal of Antimicrobial Chemotherapy
    Volume: 62
    Issue: 3
    Page numbers: 608-616
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  • Gastrointestinal infection among international travelers globally
    Year: 2008
    Journal: Journal of Travel Medicine
    Volume: 15
    Page numbers: 221-228
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  • Improving antibiotic prescribing for adults with community acquired pneumonia: does a computerised decision support system achieve more than academic detailing alone? a time series analysis
    Year: 2008
    Journal: BMC Medical Informatics and Decision Making
    Volume: 8
    Page numbers: 35
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  • Short Report: Health risks in travelers to China: The GeoSentinel experience and implications for the 2008 Beijing Olympics
    Year: 2008
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 79
    Page numbers: 4-8
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Publications in 2007

Journal Articles

  • Identifying severe community-acquired pneumonia in the emergency department: A simple clinical prediction tool


    Year: 2007
    Journal: Emergency Medicine Australasia
    Volume: 19
    Page numbers: 418-426
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  • Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1.


    Year: 2007
    Journal: Infection and Immunity
    Volume: 75
    Issue: 7
    Page numbers: 3621-3632
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  • A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD
    Year: 2007
    Journal: Respiratory Medicine
    Volume: 101
    Page numbers: 2472-2481
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  • Animal-associated injuries and related diseases among returned travellers: a review of the GeoSentinel Surveillance Network.
    Year: 2007
    Journal: Vaccine
    Volume: 25
    Page numbers: 2656-2663
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  • Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa
    Year: 2007
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 77
    Issue: 1
    Page numbers: 22-28
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  • Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Year: 2007
    Journal: American Journal of Tropical Medicine and Hygiene
    Volume: 76
    Issue: 5
    Page numbers: 860-864
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  • Catheter-related bloodstream infections in hematology
    Year: 2007
    Journal: Cancer
    Volume: 109
    Page numbers: 1215-1226
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  • Identification of basic transcriptional elements required for rif gene transcription
    Year: 2007
    Journal: International Journal for Parasitology
    Volume: 37
    Issue: 6
    Page numbers: 605-615
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  • Missed opportunities to vaccinate a cohort of hospitalised elderly with pneumococcal and influenza vaccines.
    Year: 2007
    Journal: Vaccine
    Volume: 25
    Page numbers: 5146-5154
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  • Pneumococcal polysaccharide vaccine may not prevent hospitalization for pneumonia in elderly individuals.
    Year: 2007
    Journal: Clinical Infectious Diseases
    Volume: 44
    Page numbers: 617-621
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  • Prevention of community-acquired pneumonia among a cohort of hospitalized elderly: Benefit due to influenza and pneumococcal vaccination not demonstrated.
    Year: 2007
    Journal: Vaccine
    Volume: 25
    Page numbers: 4631-4640
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  • Validity of self-reported influenza and pneumococcal vaccination status among a cohort of hospitalized elderly inpatients
    Year: 2007
    Journal: Vaccine
    Volume: 25
    Issue: 25
    Page numbers: 4775-4783
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Publications in 2006

Journal Articles

  • A prospective comparison of severity scores for identifying patients with severe community acquired pneumonia: reconsidering what is meant by severe pneumonia.
    Year: 2006
    Journal: Thorax
    Volume: 61
    Issue: 5
    Page numbers: 419-424
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  • Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies.
    Year: 2006
    Journal: Journal of Infectious Diseases
    Volume: 193
    Issue: 5
    Page numbers: 721-730
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  • Illness in returned travelers and immigrants/refugees: the 6-year experience of two Australian infectious diseases units.
    Year: 2006
    Journal: Journal of Travel Medicine
    Volume: 13
    Issue: 3
    Page numbers: 145-152
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  • Illness in travelers visiting friends and relatives: a review of the GeoSentinel Surveillance Network.
    Year: 2006
    Journal: Clinical Infectious Diseases
    Volume: 43
    Issue: 9
    Page numbers: 1185-1193
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  • Reduction of broad-spectrum antibiotic use with computerized decision support in an intensive care unit.
    Year: 2006
    Journal: International Journal for Quality in Health Care
    Volume: 18
    Issue: 3
    Page numbers: 224-231
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  • Transcribed var genes associated with placental malaria in Malawian women.
    Year: 2006
    Journal: Infection and Immunity
    Volume: 74
    Issue: 8
    Page numbers: 4875-4883
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  • VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum.
    Year: 2006
    Journal: Molecular and Biochemical Parasitology
    Volume: 148
    Issue: 2
    Page numbers: 117-124
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Publications in 2005

Journal Articles

  • Antibiotic prescribing in response to bacterial isolates in the Intensive Care Unit
    Year: 2005
    Journal: Anaesthesia and Intensive Care
    Volume: 33
    Page numbers: 571-577
    Publisher: Australian Society of Anaesthetists(Sydney)
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  • Broad analysis reveals a consistent pattern of var gene transcription in Plasmoidum falciparum repeatedly selected for a defined adhesion phenotype
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 56
    Page numbers: 774-788
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  • Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa
    Year: 2005
    Journal: Infection and Immunity
    Volume: 73
    Page numbers: 2848-2856
    Publisher: American Society for Microbiology(Washington DC)
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  • Patient knows best: blinded assessment of nonadherence with antituberculous therapy by physicians, nurses, and patients compared with urine drug levels
    Year: 2005
    Journal: Preventive Medicine
    Volume: 40
    Page numbers: 41-45
    Publisher: Academic Press(California)
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  • Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity
    Year: 2005
    Journal: Infection and Immunity
    Volume: 73
    Page numbers: 5903-5907
    Publisher: American Society for Microbiology(Washington DC)
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Publications in 2004

Journal Articles

  • Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and having overlapping and distinct targets
    Year: 2004
    Journal: Journal of Infectious Diseases
    Volume: 189
    Page numbers: 540-551
    Publisher: University of Chicago Press(Illinois)
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  • Are the Australian guidelines asking too much of the Pneumonia Severity Index (PSI)?
    Year: 2004
    Journal: Medical Journal of Australia
    Volume: 180
    Page numbers: 486-487
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  • Delayed onset of malaria - implications for chemoprophylaxis
    Year: 2004
    Journal: New England Journal of Medicine
    Volume: 350
    Page numbers: 195-197
    Publisher: Massachusetts Medical Society(Massachusetts)
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  • Imported Plasmodium vivax malaria: demographic and clinical features in nonimmune travelers
    Year: 2004
    Journal: Journal of Travel Medicine
    Volume: 11
    Page numbers: 213-219
    Publisher: BC Decker Inc(Hamilton)
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  • Malaria in travelers: a review of the GeoSentinel Surveillance Network
    Year: 2004
    Journal: Clinical Infectious Diseases
    Volume: 39
    Page numbers: 1104-1112
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  • Plasmodium falciparum-infected erythrocytes demonstrate dual specificity for adhesion to hyaluronic acid and chondroitin sulfate A and have distinct adhesive properties
    Year: 2004
    Journal: Journal of Infectious Diseases
    Volume: 189
    Page numbers: 169-179
    Publisher: University of Chicago Press(Illinois)
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Publications in 2003

Journal Articles

  • A Tribute to A. C. Brownless
    Year: 2003
    Journal: Chiron
    Volume: 5
    Issue: 10
    Page numbers: 52-53
    Publisher: The University of Melbourne Medical Society(Melbourne)
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  • A randomised controlled clinical trial of the efficacy of family-based direct observation of anti-tuberculosis treatment in an urban, developed-country setting
    Year: 2003
    Journal: International Journal of Tuberculosis and Lung Disease
    Volume: 7
    Page numbers: 848-854
    Publisher: International Union Against Tuberculosis and Lung Disease
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  • A randomised, clinical trial comparing the effetiveness of hospital and community-based reminder systems for increasing uptake of influenza and pneumococcal vaccine in hospitalised patients aged 65 years and over
    Year: 2003
    Journal: Gerontology
    Volume: 49
    Page numbers: 33-40
    Publisher: S Karger AG(Basel)
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  • Dengue fever in travelers returning from Southeast Asia
    Year: 2003
    Journal: Journal of Travel Medicine
    Volume: 10
    Page numbers: 208-213
    Publisher: BC Decker Inc(Hamilton)
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  • Phenotypic switching and var gene transcription in Plasmodium falciparum
    Year: 2003
    Journal: Advances in Experimental Medicine and Biology
    Volume: 531
    Page numbers: 149-159
    Publisher: Kluwer Academic/Plenum Publishers(New York)
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  • Regulation of antigenic variation in Plasmodium falciparum: censoring freedom of expression?
    Year: 2003
    Journal: Trends in Parasitology
    Volume: 19
    Page numbers: 121-124
    Publisher: Elsevier Science(Oxford)
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  • Respiratory tract infections in travelers: A review of the Geosentinel Surveillance Network
    Year: 2003
    Journal: Clinical Infectious Diseases
    Volume: 36
    Page numbers: 399-406
    Publisher: University Chicago Press(Illinois)
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  • Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinea children
    Year: 2003
    Journal: Vaccine
    Volume: 22
    Page numbers: 30-41
    Publisher: Elsevier Science(Oxford)
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  • The Faculty reflects - 150 years of medical history
    Year: 2003
    Journal: Chiron
    Volume: 5
    Issue: 10
    Page numbers: 60
    Publisher: The University of Melbourne Medical Society(Melbourne)
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Publications in 2002

Journal Articles

  • A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a Phse 1-2b trial in Papua New Guinea
    Year: 2002
    Journal: Journal of Infectious Diseases
    Volume: 185
    Page numbers: 820-827
    Publisher: University of Chicago Press(Illinois)
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  • Evaluating specific adhesion of Plasmodium falciparum-infected erythrocytes to immobilised hyaluronic acid with comparison to binding of mammalian cells
    Year: 2002
    Journal: International Journal for Parasitology
    Volume: 32
    Page numbers: 1245-1252
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Malaria vaccines
    Year: 2002
    Journal: Medical Journal of Australia
    Volume: 177
    Page numbers: 230-231
    Publisher: Australasian Medical Publishing Co Ltd(Sydney)
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  • Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation
    Year: 2002
    Journal: Cellular and Molecular Life Sciences
    Volume: 59
    Page numbers: 258-271
    Publisher: Birkhauser(Basel)
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  • Prospects for a vaccine against malaria
    Year: 2002
    Journal: Internal Medicine Journal
    Volume: 32
    Page numbers: 129-131
    Publisher: Blackwell Science Asia(Carlton)
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  • Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype
    Year: 2002
    Journal: Molecular Microbiology
    Volume: 43
    Page numbers: 1285-1293
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Publications in 2001

Book Chapters

  • Malaria
    Year: 2001
    Book: Principles and practice of Clinical Parasitology
    Publisher: John Wiley & Sons(Chichester)
    Authors(s):

Journal Articles

  • Fever in returned travelers: review of hospital admissions for a 3-year period
    Year: 2001
    Journal: Clinical Infectious Diseases
    Volume: 33
    Page numbers: 603-609
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  • Inhibition of adhesion of Plasmodium falciparum-infected erythrocytes by structurally defined hyaluronic acid dodecasaccharides
    Year: 2001
    Journal: Infection and Immunity
    Volume: 69
    Page numbers: 420-425
    Publisher: American Society for Microbiology(Washington DC)
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  • Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion
    Year: 2001
    Journal: Molecular and Biochemical Parasitology
    Volume: 114
    Page numbers: 227-237
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  • New agents to combat malaria
    Year: 2001
    Journal: Nature Medicine
    Volume: 7
    Issue: 2
    Page numbers: 149-150
    Publisher: Nature America(New York)
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  • Parasite adhesion and immune evasion in placental malaria
    Year: 2001
    Journal: Trends in Parasitology
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  • Risk factors for colonization with vancomycin-resistant enterococci in a Melbourne hospital
    Year: 2001
    Journal: Infection Control and Hospital Epidemiology
    Volume: 22
    Page numbers: 624-629
    Publisher: Slack(New Jersey)
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