University home page

Find an ExpertProfiling the University of Melbourne's Researchers

PROF TREVOR KILPATRICK



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: DIRECTOR - CENTRE FOR NEUROSCIENCE
Email:
Work: 03 8344 1804
Fax: 03 9349 5917
Room: 227
Level: 02
Building: Alan Gilbert Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Demyelinating Diseases Multiple sclerosis Australia

International Linkages

Country Establishment Collaboration
Canada McGill University Research
United Kingdom University of Bristol Research
United States of America Salk Institute Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Surgery University of Melbourne 11-Dec-1982
Bachelor of Medicine University of Melbourne 11-Dec-1982
Doctor of Philosophy University of Melbourne 04-Aug-1993

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian and New Zealand Association of Neurologists Member 01-Jan-1990
Member Society for Neuroscience Regular Member 03-Jan-2005 31-Dec-2007
Member American Academy of Neurology Associate International 01-Jan-1997 31-Dec-2006

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 30-Apr-1990

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) NSW Office for Science and Medical Research Jamie Callachor Eureka Prize for Medical Research 19-Aug-2008
Scholarship University of Melbourne Robert Gartley Healy Scholarship - Obstretrics 11-Dec-1982
Scholarship University of Melbourne Beany Scholarship - Surgery 11-Dec-1982
Scholarship The Royal Australasian College of Physicians TF Ryan Scholarship and Medal 11-Dec-1982
Scholarship University of Melbourne Robert Gartley Healy Scholarship - Surgery 11-Dec-1982
Other (Award) Australian Association of Neurologists Leonard Bell Cox Award 16-May-2000
Other (Award) Australian Neuroscience Society Sunderland Award 30-Nov-1994
Other (Award) Bethlehem Griffiths Research Foundation Award for Medical Research 03-Jun-2004
Other (Award) AMRAD Corporation Ltd AMRAD Post-Doctoral Award for excellence in biomedical research 03-Jun-1996

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
CENTRE FOR NEUROSCIENCE Chief Investigator HOWARD FLOREY INST,
SCHERING AUST PTY LTD
Research Grant (HOWARD FLOREY INST) 09/10/2002
Dynamic balance intervention to improve gait and balance in people recently diagnosed with multiple sclerosis: a pilot study Chief Investigator MS AUSTRALIA Seeding Grants 12/11/2003
ROLE OF SOCS 3 IN REGULATING OLIGODENDROGLIAL PHENOTYPE IN HEALTH AND DISEASE Chief Investigator NHMRC Project Grants 01/01/2005
Predicting disease outcome in patients with early multiple sclerosis Principal Supervisor NHMRC Medical & Dental Postgraduate Scholarships 01/01/2005
CENTRE FOR ADVANCED CELL LABELLING AND IMAGING Chief Investigator UNIVERSITY OF QUEENSLAND Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2006
CHARACTERISING THE GENETIC REGULATION OF CEELULAR REPAIR RESPONSES FOLLOWING OLIGODENDROCYTE APOPTOSIS AND DYSFUNCTION IN MOUSE MODELS OF CENTRAL NERVOUS SYSTEM DEMYELINATION Principal Supervisor Funding Partners Scholarship 01/01/2006
Assessment of gene expression as a predictor of multiple sclerosis and its severity Chief Investigator EQUITY TRUSTEES Equity Trustees Charitable Trusts (Sole Trustee) 01/09/2006
Identifying genes that influence clinical course and susceptibility in multiple sclerosis Chief Investigator MS AUSTRALIA Project Grants 28/02/2007
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease Chief Investigator BRAIN FOUNDATION,
REBECCA L COOPER MEDICAL RESEARCH FOUNDATION LTD,
AUST GENOME RESEARCH FACILITY,
ST VINCENTS HOSPITAL,
ROYAL NORTH SHORE HOSPITAL,
AUST RESEARCH COUNCIL,
MILLENNIUM SCIENCE
Linkage Projects (AUST RESEARCH COUNCIL) 21/05/2007
Identifying genes that influence clinical course and susceptibility in multiple sclerosis Chief Investigator JOHN HUNTER CHILDREN'S HOSPITAL,
MULTIPLE SCLEROSIS RESEARCH AUST,
SYDNEY WEST AREA HEALTH SERVICE,
AUST RESEARCH COUNCIL
Linkage Projects (AUST RESEARCH COUNCIL) 01/07/2007
Protecting the nervous system from inflammation Chief Investigator NHMRC Project Grants 01/01/2008
CLINICAL - DIFFUSION MRI TO ASSESS AXONAL DEGENERATION IN MULTIPLE SCLEROSIS Principal Supervisor NHMRC Scholarships 01/01/2008
Analysing how key molecules protect the nervous system in Multiple Sclerosis Chief Investigator NHMRC Project Grants 01/01/2009
The role of NDFIP1 in neural stem cell survival and their generation into neurons Chief Investigator NHMRC Project Grants 01/01/2009
DEVELOPMENT AND REFINEMENT OF NEURAL CONNECTIONS IN THE ADULT BRAIN IN HEALTH AND DISEASE Chief Investigator UNIVERSITY OF QUEENSLAND Program Grants (NHMRC) 01/01/2009
Development of a magnetic resonance imaging (MRI) platform to evaluate neuroprotective and regenerative therapies in MS Principal Supervisor GLAXOSMITHKLINE AUSTRALIA GSK Post Graduate Support Grant 01/04/2009
To determine whether changes in TAM receptor signalling genes influence susceptibility to MS Chief Investigator PERPETUAL TRUSTEES AUST LTD MISCELLANEOUS TRUSTS 01/09/2009

Contracts

Title Role Funding Source Award Date
Identification of novel genes involved in the oligodendroglial response to injury Chief Investigator NEUROSCIENCES VIC 01/04/2004
SCHERING RESEARCH PROJECT: INVESTIGATION OF DEMYELINATION IN A MULTIPLE SCLEROSIS MOUSE MODEL USING MRI Chief Investigator NEUROSCIENCES VIC 01/05/2006
DEVELOPMENT OF A MAGNETIC RESONANCE IMAGING-BASED PLATFORM TO ENABLE TESTING OF NEUROPROTECTIVE AND REGENERATIVE THERAPIES IN MULTIPLE SCLEROSIS Chief Investigator BIOGEN IDEC INC 01/03/2007
NEUROLOGY RESEARCH GRANT Chief Investigator BAYER AUSTRALIA LTD 30/10/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Multiple sclerosis: Cognition and saccadic eye movements


    Year: 2009
    Journal: Journal of the Neurological Sciences
    Volume: 277
    Page numbers: 32-36
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Antisaccade performance in patients with multiple sclerosis
    Year: 2009
    Journal: Cortex
    Volume: 45
    Page numbers: 900-903
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • BDNF Exerts Contrasting Effects on Peripheral Myelination
    of NGF-Dependent and BDNF-Dependent DRG Neurons
    Year: 2009
    Journal: Journal of Neuroscience
    Volume: 29
    Issue: 13
    Page numbers: 4016-4022
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Control of visually-guided saccades in Multiple Sclerosis: Disruption to higher order processes
    Year: 2009
    Journal: Neuropsychologia
    Volume: 47
    Page numbers: 1647-1653
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layering
    Year: 2009
    Journal: Glia
    Volume: 57
    Page numbers: 1024-1030
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis
    Year: 2009
    Journal: Neuroimage
    Volume: 45
    Page numbers: 679-686
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The Role of Neurotrophins in the Regulation of Myelin Development
    Year: 2009
    Journal: Neurosignals
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2008

Journal Articles

  • CD127 immunophenotyping suggests altered CD4+ T cell regulation in primary progressive multiple sclerosis


    Year: 2008
    Journal: Journal of Autoimmunity
    Volume: 31
    Page numbers: 52-58
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis


    Year: 2008
    Journal: Genes and Immunity
    Volume: 9
    Page numbers: 1-6
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Oligodendrocyte positioning in cerebral cortex is independant of projection neuron layering


    Year: 2008
    Journal: Glia
    Volume: 1002
    Page numbers: 2082-6
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com.ezp.lib.unimelb.edu.au/cgi-bin/fulltext/121549530/HTMLSTART
    Super Search Source this item in the University's Catalouge locate this resource.
  • Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians


    Year: 2008
    Journal: Genes and Immunity
    Volume: 9
    Page numbers: 624-360
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians


    Year: 2008
    Journal: Tissue Antigens
    Volume: 71
    Page numbers: 42-50
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Validation of a Novel Biomarker for Acute Axonal Injury in Experimental Autoimmune Encephalomyelitis


    Year: 2008
    Journal: Journal of Neuroscience Research
    Volume: 86
    Page numbers: 3548-3555
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Validation of linear cerebral atrophy markers in multiple sclerosis


    Year: 2008
    Journal: Journal of Clinical Neuroscience
    Volume: 15
    Page numbers: 130-137
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Effectiveness of rehabilitation intervention in persons with multiple sclerosis: a randomised controlled trial.
    Year: 2008
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    Volume: 79
    Issue: 11
    Page numbers: 1230-1235
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 20
    Page numbers: 5195-5206
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair
    Year: 2008
    Journal: Glia
    Volume: 56
    Page numbers: 686-698
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • MRI identification of the rostral-caudal pattern of pathology within the corpus callosum in the cuprizone mouse model
    Year: 2008
    Journal: Journal of Magnetic Resonance Imaging
    Volume: 27
    Issue: 3
    Page numbers: 446-453
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Multidisciplinary rehabilitation for adults with multiple sclerosis
    Year: 2008
    Journal: Postgraduate Medical Journal
    Volume: 84
    Page numbers: 385
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotrophin receptor homolog-2 regulates nerve growth factor signaling
    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 106
    Page numbers: 1964-76
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2007

Journal Articles

  • Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients
    Year: 2007
    Journal: Immunogenetics
    Volume: 59
    Issue: 3
    Page numbers: 177-86
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Illness perception and health-related quality of life in multiple sclerosis
    Year: 2007
    Journal: Acta Neurologica Scandinavica
    Volume: 116
    Page numbers: 293-299
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • MR diffusion changes correlate with ultrastructurally defined axonal degeneration in murine optic nerve
    Year: 2007
    Journal: Neuroimage
    Volume: 37
    Issue: 4
    Page numbers: 1138-1147
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17689104&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
    Super Search Source this item in the University's Catalouge locate this resource.
  • Observational analytic studies in multiple sclerosis: controlling bias through study design and conduct. The Australian Multicentre Study of Environment and Immune Function.
    Year: 2007
    Journal: Multiple Sclerosis
    Volume: 13
    Issue: 7
    Page numbers: 827-39
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia.
    Year: 2007
    Journal: Journal of Neurology
    Volume: 254
    Page numbers: 581-590
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Major Reference Works

  • Cochrane Database of Systematic Reviews 2007:Multidisciplinary rehabilitation for adults with multiple sclerosis.
    Year: 2007
    Reference Work Title: Cochrane Database of Systematic Reviews 2007
    Publisher: Wiley - John Wiley & Sons(London)
    Author(s):

Publications in 2006

Journal Articles

  • Endogenous Leukemia Inhibitory Factor Production Limits Autoimmune Demyelination and Oligodendrocyte Loss


    Year: 2006
    Journal: Glia
    Volume: 53
    Issue: 2006
    Page numbers: 696-703
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gait and balance impairment in early multiple sclerosis
    in the absence of clinical disability


    Year: 2006
    Journal: Multiple Sclerosis
    Volume: 12
    Issue: 5
    Page numbers: 620-628
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Asthma onset prior to multiple sclerosis and the contribution of sibling exposure in early life
    Year: 2006
    Journal: Clinical and Experimental Immunology
    Volume: 146
    Page numbers: 463-470
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Multiple sclerosis: disability profile and quality of life in an Australian community cohort.
    Year: 2006
    Journal: International Journal of Rehabilitation Research
    Volume: 29
    Page numbers: 87-96
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor.
    Year: 2006
    Journal: Neuroscience
    Volume: 137
    Issue: 2006
    Page numbers: 463-472
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • On the utility of data from the International HapMap Project for Australian association studies
    Year: 2006
    Journal: Human Genetics
    Volume: 119
    Issue: 1
    Page numbers: 220-222
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • SOCS3 negatively regulates LIF signaling in neural precursor cells.
    Year: 2006
    Journal: Molecular and Cellular Neurosciences
    Volume: 31
    Issue: 4
    Page numbers: 739-747
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses.
    Year: 2006
    Journal: Journal of Clinical Neuroscience
    Volume: 13
    Page numbers: 636-638
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 20
    Page numbers: 7859-7864
    Author(s):
    URL - restricted access www.pnas.org/cgi/doi/10.1073/pnas.0602574103
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Book Chapters

  • Multiple sclerosis: a hapoltype association study
    Year: 2005
    Book: The genetics of autoimmunity
    Publisher: Wiley-VCH(Weinheim)
    Authors(s):

Journal Articles

  • Exposure to infant siblings during early life and risk of multiple sclerosis
    Year: 2005
    Journal: JAMA - Journal of the American Medical Association
    Volume: 293
    Issue: 4
    Page numbers: 463-469
    Publisher: American Medical Association(Illinois)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Multiple sclerosis severity score: using disability and disease duration to rate disease severity
    Year: 2005
    Journal: Neurology
    Volume: 64(7)
    Page numbers: 1144-1151
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Book Chapters

  • The role of neurotransmission and the Chopper domain in p75 neurotrophin receptor death signaling
    Year: 2004
    Book: NGF and Related Molecules in Health and Disease (146 Progress in Brain Research)
    Publisher: Elsevier(Amsterdam)
    Authors(s):

Journal Articles

  • Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis
    Year: 2004
    Journal: Internal Medicine Journal
    Volume: 34
    Page numbers: 66-69
    Publisher: Blackwell Science Asia(Carlton)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Effect of 075 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice
    Year: 2004
    Journal: Journal of Neuroscience Research
    Volume: 78
    Page numbers: 193-199
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Expression of the low-affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination
    Year: 2004
    Journal: Glia
    Volume: 48
    Issue: 1
    Page numbers: 64-75
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis
    Year: 2004
    Journal: Human Genetics
    Volume: 114
    Page numbers: 573-580
    Publisher: Springer Verlag(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • LIF receptor signaling modulates neural stem cell renewal
    Year: 2004
    Journal: Molecular and Cellular Neurosciences
    Volume: 27
    Page numbers: 255-266
    Publisher: Academic Press
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neuroglial responses to CNS injury: prospects for novel therapeutics
    Year: 2004
    Journal: Expert Review of Neurotherapeutics
    Volume: 4(5)
    Issue: 2004
    Page numbers: 869-878
    Publisher: Future Drugs(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy
    Year: 2004
    Journal: Journal of Clinical Neuroscience
    Volume: 11
    Issue: 2
    Page numbers: 153-158
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Journal Articles

  • A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer
    Year: 2003
    Journal: Clinical Cancer Research
    Volume: 9
    Page numbers: 2056-2065
    Publisher: American Association for Cancer Research(Alabama)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
    Year: 2003
    Journal: British Medical Journal
    Volume: 327
    Page numbers: 1-6
    Publisher: BMJ Publishing Group(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor
    Year: 2003
    Journal: Journal of Neuropathology and Experimental Neurology
    Volume: 62
    Page numbers: 398-411
    Publisher: American Association of Neuropathologists Inc(Kansas)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Journal Articles

  • Genetic dissection of the HLA Region Using Haplotypes of Tasmanians with multiple sclerosis
    Year: 2002
    Journal: American Journal of Human Genetics
    Volume: 70
    Page numbers: 1125-1137
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis
    Year: 2002
    Journal: American Journal of Human Genetics
    Volume: 70
    Page numbers: 1125-1137
    Publisher: University of Chicago Press(Illinois)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
    Year: 2002
    Journal: Nature Medicine
    Volume: 8
    Issue: 6
    Page numbers: 613-619
    Publisher: Nature America(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Prospects for stem cell transplantation in multiple sclerosis
    Year: 2002
    Journal: Journal of Clinical Neuroscience
    Volume: 9
    Issue: 4
    Page numbers: 361-367
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Prospects for stem cell transplantation in mutiple sclerosis
    Year: 2002
    Journal: Journal of Clinical Neuroscience
    Volume: 9
    Page numbers: 361-367
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
top of page