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DR MICHAEL MCKINLEY



Contact Details

Organization: Physiology
Position: Honorary (Senior Fellow)
Email:
Homepage: http://www.hfi.unimelb.edu.au/content/personnel/hm_mmathai.html
Work: 83447303
Fax: 9348 1707
Room: 319
Level: 03
Building: Howard Florey
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Fluid homeostasis Lamina terminalis, angiotensin, vasopressin, thirst, thermoregulation Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Dr University of Melbourne 04-Apr-1998

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Brain angiotensin: generation, localisation and physiological function Chief Investigator NHMRC Project Grants 01/01/2004
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2004
Neural mechanisms mediating inhibitory influences of hyperthermia, fever and age on water intake Chief Investigator NHMRC Project Grants 01/01/2004
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
Brain pathways for temperature and fever Chief Investigator NHMRC Project Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - MCKINLEY Chief Investigator NHMRC Research Fellowship 01/01/2007
Brain pathways for heat defence Chief Investigator NHMRC Project Grants 01/01/2010
Sympathetic Immune Crosstalk Chief Investigator NHMRC Project Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Effect of ageing on regional cerebral blood flow responses associated with osmotic thirst and its satiation by water drinking: a positron emission tomography study


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 1
    Page numbers: 382-387
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  • Central nitric oxide synthase inhibition restores behaviorally mediated lipopolysaccharide induced feber in near-term rats
    Year: 2008
    Journal: Physiology & Behavior
    Volume: 94
    Page numbers: 630-634
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  • Central osmoregulatory influences on thermoregulation
    Year: 2008
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 35
    Issue: 5-6
    Page numbers: 701-705
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  • Effect of aging on regional cerebral blood flow responses associated with osmotic thirst and its satiation by water drinking: a PET study
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 1
    Page numbers: 382-387
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  • Effect of central urotensin II on heart rate, blood pressure and brain Fos immunoreactivity in conscious rats
    Year: 2008
    Journal: Neuroscience
    Volume: 155
    Page numbers: 241-249
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  • Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 18
    Page numbers: 6531-6536
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  • Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice
    lacking angiotensin
    Year: 2008
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 294
    Issue: 5
    Page numbers: R1533-43
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  • The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst
    Year: 2008
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 294
    Page numbers: R1390-R1401
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Publications in 2007

Journal Articles

  • Differential effects of intravenous hyperosmotic solutes on drinking latency and c-Fos expression in the circumventricular organs and hypothalamus of the rat
    Year: 2007
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 292
    Page numbers: R1690-R1698
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  • Independent vasomotor control of rat tail and proximal hairy skin
    Year: 2007
    Journal: The Journal of Physiology
    Volume: 582
    Issue: 1
    Page numbers: 421-433
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  • Investigation of the mechanisms by which chronic infusion of an acutely subpressor dose of angiotensin II induces hypertension
    Year: 2007
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 292
    Page numbers: R1893-R1899
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  • Suppression of endotoxin-induced fever in near-term pregnant rats is mediated by brain nitric oxide
    Year: 2007
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 292
    Page numbers: R2174-R2178
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Publications in 2006

Journal Articles

  • Human medullary responses to cooling and rewarming the skin: A functional MRI study
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 2006
    Page numbers: 809-813
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Publications in 2005

Journal Articles

  • Amylin induces natriuresis by a central angiotensin-dependent mechanism
    Year: 2005
    Journal: Regulatory Peptides
    Volume: 130
    Page numbers: 91-96
    Publisher: Elsevier Science(Amsterdam)
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  • Angiotensinogen and angiotensin-converting enzyme gene copy number and angiotensin and bradykinin peptide levels in mice
    Year: 2005
    Journal: Journal of Hypertension
    Volume: 23
    Page numbers: 945-954
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Cortical, thalamic, and hypothalamic responses to cooling and warming the skin in awake humans: A positron-emission tomography study
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 14
    Page numbers: 5262-5267
    Publisher: National Academy of Sciences(Washington DC)
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  • Influence of brain angiotensin on thermoregulation and hydromineral balance during pregnancy in rats
    Year: 2005
    Journal: Journal of Applied Physiology
    Volume: 98
    Issue: 5
    Page numbers: 1813-1819
    Publisher: American Physiological Society(Maryland)
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  • Personal body maps
    Year: 2005
    Journal: American Journal of Physiology - Regulatory Integrative Comparative Physiology
    Volume: 289
    Page numbers: R317-R318
    Publisher: American Physiological Society(Maryland)
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Publications in 2004

Book Chapters

  • Angiotensin actions on the brain influencing salt and water balance
    Year: 2004
    Book: Angiotensin
    Publisher: Springer-Verlag Heidelberg(Heidelberg)
    Authors(s):
  • Circumventricular organs
    Year: 2004
    Book: The Human Nervous System
    Publisher: Elsevier(California)
    Authors(s):
  • Circumventricular organs
    Year: 2004
    Book: The Rat Nervous System
    Publisher: Academic Press(San Diego)
    Authors(s):

Journal Articles

  • Central blockade of nitric oxide synthesis induces hyperthermia that is prevented by indomethacin in rats
    Year: 2004
    Journal: Journal of Thermal Biology
    Volume: 29
    Page numbers: 401-405
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
    Year: 2004
    Journal: Hypertension
    Volume: 43
    Issue: 4
    Page numbers: 854-859
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • Physiological and pathophysiological influences on thirst
    Year: 2004
    Journal: Physiology & Behavior
    Volume: 81
    Page numbers: 795-803
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  • The physiological regulation of thirst and fluid intake
    Year: 2004
    Journal: News in Physiological Sciences
    Volume: 19
    Page numbers: 1-6
    Publisher: American Psychological Association(Washington DC)
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  • Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis
    Year: 2004
    Journal: Journal of Neuroendocrinology
    Volume: 16
    Page numbers: 340-347
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Publications in 2003

Books

  • The sensory circumventricular organs of the mammalian brain
    Year: 2003
    Publisher: Springer Verlag(Berlin)
    Authors(s):

Journal Articles

  • Circulating angiotensin II activates neurones in circumventricular organs of the lamina terminalis that project to the bed nucleus of the stria terminalis
    Year: 2003
    Journal: Journal of Neuroendocrinology
    Volume: 15
    Issue: 8
    Page numbers: 725-731
    Publisher: Blackwell Science(Oxford)
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  • Neural correlates of the emergence of consciousness of thirst
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 25
    Page numbers: 15241-15246
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  • The brain renin-angiotensin system: location and physiological roles
    Year: 2003
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 35
    Issue: 6
    Page numbers: 901-918
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  • The effect of urocortin on ingestive behaviours and brain Fos immunoreactivity in mice
    Year: 2003
    Journal: European Journal of Neuroscience
    Volume: 18
    Issue: 2
    Page numbers: 373-382
    Publisher: Blackwell Science(Oxford)
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Publications in 2002

Journal Articles

  • The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat
    Year: 2002
    Journal: Neuroscience
    Volume: 110
    Page numbers: 515-526
    Publisher: Pergamon-Elsevier Science(Oxford)
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