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A/PROF ROBERTO CAPPAI



Contact Details

Organization: Pathology
Position: PRINCIPAL RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/cappai/
Work: 8344 2556
Fax: 9347 6750
Room: 470
Level: 04
Building: David Pennington Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Prion disease, protein chemistry, protein misfolding Australia

International Linkages

Country Establishment Collaboration
India University of Madras Research, Teaching, Technical Assistance/Training
Germany Max-Delbruck-Center for Molecular Medicine Research
United Kingdom University of Nottingham Research
Sweden Lund University Research
Germany Free University of Berlin Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honours) Monash University 31-Dec-1987
Doctor of Philosophy University of Melbourne 30-Aug-1991

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society 01-Jan-2001
Member Society for Neuroscience 01-Jan-2001
Member International Society for Neurochemistry 31-Jan-2005
Member Asian-Pacific Society for Neurochemistry 30-Jun-2006
Member Australian Society for Biochemistry and Molecular Biology 01-Jan-2002

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
INITIAL APPOINTMENT AT SRF LEVEL A; PROMOTED IN 2006 Chief Investigator NHMRC Research Fellowship 01/01/2004
Identification & characterisation of genes involved in the copper regulation of the human Alzheimer's disease Amyloid-beta Precursor Protein(APP) gene Chief Investigator AUST RESEARCH COUNCIL Discovery Indigenous Researchers Development Scheme 01/01/2005
Delineating the role of the GxxxG motif in transmembrane protein metabolism Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
Understanding the interaction between the Amyloid Precursor Protein family and sorLA Chief Investigator NHMRC Project Grants 01/01/2008
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008

Contracts

Title Role Funding Source Award Date
Prana Biotechnology Ltd Agreement Chief Investigator PRANA BIOTECHNOLOGY LTD 11/04/2003
SECOND AND THIRD RESEARCH FUNDING AND IP ASSIGNMENT AGREEMENT (PRANA) Chief Investigator PRANA BIOTECHNOLOGY LTD 01/12/2003
NSV_42_05_SAG21 (P2) : EXPRESSION PROFILING OF AD IMAGING TARGETS Chief Investigator NEUROSCIENCES VIC 02/12/2003
NSV_043_05_SAG22 (P3) : AMYLOID IMAGING WITH 18F-AB LIGAND AND PET Chief Investigator NEUROSCIENCES VIC 02/12/2003
NSV_041_05_SAG20 (P1) : AMYLOID AB IMAGING LIGANDS : A HIGH THROUGHPUT SCREEN APPROACH - CHARACTERISATION OF AB BINDING COMPOUNDS Chief Investigator NEUROSCIENCES VIC 01/12/2005

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
    Author(s):
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  •  Monitoring the prevention of amyloid fibril formation by α-crystallin.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Issue: 24
    Page numbers: 6290-304
    Author(s):
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  • Molecular determinants of Alzheimer's diesase AB peptide neurotoxicity


    Year: 2007
    Journal: Future Neurology
    Volume: 2
    Issue: 4
    Page numbers: 397-409
    Author(s):
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  • Packaging of prions into exosomes is associated with a novel pathway of PrP processing.


    Year: 2007
    Journal: Journal of Pathology
    Volume: 211
    Issue: 5
    Page numbers: 582-590
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  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease
    Year: 2007
    Journal: Experimental Neurology
    Volume: 204
    Issue: 2
    Page numbers: 583-588
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  • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
    Year: 2007
    Journal: Journal of Molecular Biology
    Volume: 367
    Issue: 1
    Page numbers: 148-161
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17239395?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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  • Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution
    Year: 2007
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: 63
    Issue: 10
    Page numbers: 819-824
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  • The redox chemistry of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 1976-1990
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Major Reference Works

  • Handbook of Metalloproteins:Amyloid precursor protein
    Year: 2007
    Reference Work Title: Handbook of Metalloproteins
    Publisher: John Wiley & Sons
    Author(s):

Publications in 2006

Book Chapters

  • The Function of the Amyloid Precursor Protein Family
    Year: 2006
    Book: Abeta Peptide and Alzheimer's Disease
    Publisher: Springer Verlag
    Authors(s):

Journal Articles

  • Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human Amyloid Precursor Protein
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 357
    Page numbers: 493-508
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  •  Alois Alzheimer and Alzheimer’s disease:  a centennial perspective
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 99
    Page numbers: 708-710
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  • 6-hydroxy-dopamine but not 1-methyl-4-phenylpyridinium abolishes α-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 14
    Page numbers: 9824-9831
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  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
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  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
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  • Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease.
    Year: 2006
    Journal: Neurobiology of Aging
    Volume: 27
    Page numbers: 614-623
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  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
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  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
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  • Molecular Dissection of the Interaction Between APP and Its Neuronal Trafficking Receptor SorLA/LR11
    Year: 2006
    Journal: Biochemistry
    Volume: 45
    Page numbers: 2618-2628
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  • Molecular mechanisms for Alzheimer ’s disease: implications for neuroimaging and therapeutics
    Year: 2006
    Journal: Journal of Neurochemistry