University home page

Find an ExpertProfiling the University of Melbourne's Researchers

A/PROF ROBERTO CAPPAI



Contact Details

Organization: Pathology
Position: ACTING HEAD OF DEPARTMENT
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/cappai/
Room: W506
Level: 05
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Prion disease, protein chemistry, protein misfolding Australia

International Linkages

Country Establishment Collaboration
Austria University of Graz Research
Germany Free University of Berlin Research
Sweden Lund University Research
India University of Madras Research, Teaching, Technical Assistance/Training
Germany Max-Delbruck-Center for Molecular Medicine Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honours) Monash University 31-Dec-1987
Doctor of Philosophy University of Melbourne 30-Aug-1991

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society Regular 01-Jan-2001
Member Society for Neuroscience Regular 01-Jan-2001
Member International Society for Neurochemistry Regular 31-Jan-2005
Member Asian-Pacific Society for Neurochemistry Regular 30-Jun-2006
Member Australian Society for Biochemistry and Molecular Biology Regular 01-Jan-2002

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
INITIAL APPOINTMENT AT SRF LEVEL A; PROMOTED IN 2006 Chief Investigator NHMRC Research Fellowship 01/01/2004
Identification & characterisation of genes involved in the copper regulation of the human Alzheimer's disease Amyloid-beta Precursor Protein(APP) gene Chief Investigator AUST RESEARCH COUNCIL Discovery Indigenous Researchers Development Scheme 01/01/2005
Delineating the role of the GxxxG motif in transmembrane protein metabolism Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
Understanding the interaction between the Amyloid Precursor Protein family and sorLA Chief Investigator NHMRC Project Grants 01/01/2008
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
DELINEATING THE ROLE OF THE GXXXG MOTIF IN ALZHEIMER'S DISEASE Chief Investigator UNIVERSITY OF MELBOURNE,
ALZHEIMER'S AUST RESEARCH LTD
Viertel Foundation Postdoctoral Fellowship in Dementia (ALZHEIMER'S AUST RESEARCH LTD) 01/01/2009
NHMRC Research Fellowship 2009 - CAPPAI Chief Investigator NHMRC Research Fellowship 01/01/2009
Studies on the structure and dynamics of misfolding proteins in neurodegenerative diseases Chief Investigator AINSE Awards 01/01/2009

Contracts

Title Role Funding Source Award Date
Prana Biotechnology Ltd Agreement Chief Investigator PRANA BIOTECHNOLOGY LTD 11/04/2003
SECOND AND THIRD RESEARCH FUNDING AND IP ASSIGNMENT AGREEMENT (PRANA) Chief Investigator PRANA BIOTECHNOLOGY LTD 01/12/2003
NSV_42_05_SAG21 (P2) : EXPRESSION PROFILING OF AD IMAGING TARGETS Chief Investigator NEUROSCIENCES VIC 02/12/2003
NSV_043_05_SAG22 (P3) : AMYLOID IMAGING WITH 18F-AB LIGAND AND PET Chief Investigator NEUROSCIENCES VIC 02/12/2003
NSV_041_05_SAG20 (P1) : AMYLOID AB IMAGING LIGANDS : A HIGH THROUGHPUT SCREEN APPROACH - CHARACTERISATION OF AB BINDING COMPOUNDS Chief Investigator NEUROSCIENCES VIC 01/12/2005
CHARACTERISING AMYLOID IMAGING AGENTS Chief Investigator THE MENTAL HEALTH RESEARCH INST 26/09/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Dopamine and the Dopamine Oxidation Product5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner.


     


    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 387
    Page numbers: 771-785
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Formation of depamine-mediated α-synuclein-soluble oligomers requires methionine oxidation.


     


    Year: 2009
    Journal: Free Radical Biology and Medicine
    Volume: 46
    Page numbers: 1328-1337
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies


    Year: 2009
    Journal: European Journal of Pharmacology
    Volume: 617
    Page numbers: 54-58
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Characterization of PiB binding to white matter in Alzheimer disease and other dementias
    Year: 2009
    Journal: Journal of Nuclear Medicine
    Volume: 50
    Issue: 2
    Page numbers: 198-204
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 2
    Page numbers: 381-386
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Stimulus pattern dependence of the Alzheimer disease Aβ42 peptide's inhibition of long term potentiation in mouse hippocampal slices.
    Year: 2009
    Journal: Brain Research
    Volume: 1269
    Page numbers: 176-184
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2008

Book Chapters

  • Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press
    Authors(s):

Journal Articles

  • Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity


    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 46
    Page numbers: 11950-11958
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Amyloid-β-Anti-Amyloid-β Complex Structure Reveals an Extended confirmation in the Immunodominant B-Cell Epitope


    Year: 2008
    Journal: Journal of Molecular Biology
    Volume: 377
    Issue: 1
    Page numbers: 181-192
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper binding to the Alzheimer's disease amyloid precursor protein


    Year: 2008
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 37
    Issue: 3
    Page numbers: 269-279
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer’s disease


    Year: 2008
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: n/a
    Issue: F64
    Page numbers: 438-441
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity


    Year: 2008
    Journal: Neurochemical Research
    Volume: 33
    Issue: 3
    Page numbers: 526-532
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Dimeric structures of α-synuclein bind preferentially to lipid membranes


    Year: 2008
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1778
    Issue: 4
    Page numbers: 1112-1119
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Identification of the Alzheimer’s disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth


    Year: 2008
    Journal: Journal of Pathology
    Volume: 215
    Issue: 2008
    Page numbers: 155-163
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 12
    Page numbers: 2793-2801
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation


    Year: 2008
    Journal: Free Radical Biology and Medicine
    Volume: 44
    Issue: 1
    Page numbers: 44-55
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 106
    Issue: 2
    Page numbers: 793-804
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • An update on the toxicity of Aβ in Alzheimer's disease
    Year: 2008
    Journal: Neuropsychiatric Disease and Treatment
    Volume: 4
    Issue: 6
    Page numbers: 1033 - 1042
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cu2+ Binding Modes of Recombinant α-Synuclein – Insights from EPR Spectroscopy
    Year: 2008
    Journal: Journal of the American Chemical Society
    Volume: 130
    Issue: 24
    Page numbers: 7766-7773
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid
    Year: 2008
    Journal: Veterinary Immunology and Immunopathology
    Volume: 124
    Issue: 3-4
    Page numbers: 385-393
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine
    Year: 2008
    Journal: Autonomic Neuroscience - Basic & Clinical
    Volume: 140
    Page numbers: 17-23
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Issue: 5
    Page numbers: 1425-1434
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Rapid Restoration of Cognition in Alzheimer’s Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
    Year: 2008
    Journal: Neuron
    Volume: 59
    Issue: 1
    Page numbers: 43-55
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer’s Disease Amyloid-β Peptide
    Year: 2008
    Journal: Biophysical Journal
    Volume: 94
    Page numbers: 2752-2766
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The ART of Loss: Aβ Imaging in the Evaluation of Alzheimer’s Disease and other Dementias
    Year: 2008
    Journal: Molecular Neurobiology: a review journal
    Volume: 38
    Issue: 1
    Page numbers: 1-15
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  •  Monitoring the prevention of amyloid fibril formation by α-crystallin.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Issue: 24
    Page numbers: 6290-304
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Molecular determinants of Alzheimer's diesase AB peptide neurotoxicity


    Year: 2007
    Journal: Future Neurology
    Volume: 2
    Issue: 4
    Page numbers: 397-409
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Packaging of prions into exosomes is associated with a novel pathway of PrP processing.


    Year: 2007
    Journal: Journal of Pathology
    Volume: 211
    Issue: 5
    Page numbers: 582-590
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease
    Year: 2007
    Journal: Experimental Neurology
    Volume: 204
    Issue: 2
    Page numbers: 583-588
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
    Year: 2007
    Journal: Journal of Molecular Biology
    Volume: 367
    Issue: 1
    Page numbers: 148-161
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17239395?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
    Super Search Source this item in the University's Catalouge locate this resource.
  • Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution
    Year: 2007
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: 63
    Issue: 10
    Page numbers: 819-824
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The redox chemistry of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 1976-1990
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Major Reference Works

  • Handbook of Metalloproteins:Amyloid precursor protein
    Year: 2007
    Reference Work Title: Handbook of Metalloproteins
    Publisher: John Wiley & Sons
    Author(s):

Publications in 2006

Book Chapters

  • The Function of the Amyloid Precursor Protein Family
    Year: 2006
    Book: Abeta Peptide and Alzheimer's Disease
    Publisher: Springer Verlag
    Authors(s):

Journal Articles

  • Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human Amyloid Precursor Protein
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 357
    Page numbers: 493-508
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  •  Alois Alzheimer and Alzheimer’s disease:  a centennial perspective
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 99
    Page numbers: 708-710
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • 6-hydroxy-dopamine but not 1-methyl-4-phenylpyridinium abolishes α-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 14
    Page numbers: 9824-9831
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease.
    Year: 2006
    Journal: Neurobiology of Aging
    Volume: 27
    Page numbers: 614-623
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gender and genetic background effects on brain metals homeostasis in APP transgenic and normal mice: implications for Alzheimer β-amyloid pathology.
    Year: 2006
    Journal: Journal of Inorganic Biochemistry
    Volume: 100
    Issue: 5-6
    Page numbers: 952-962
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Molecular Dissection of the Interaction Between APP and Its Neuronal Trafficking Receptor SorLA/LR11
    Year: 2006
    Journal: Biochemistry
    Volume: 45
    Page numbers: 2618-2628
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Molecular mechanisms for Alzheimer ’s disease: implications for neuroimaging and therapeutics
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 97
    Page numbers: 1700-1725
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Book Chapters

  • Mechanisms of prion toxicity and its relation to prion infectivity
    Year: 2005
    Book: Neurodegeneration and Prion disease
    Publisher: Springer Verlag(New York)
    Authors(s):
  • Strategies for crystallizing the N-terminal, growth factor domain of amyloid precursor protein
    Year: 2005
    Book: Amyloid Precursor Protein. A Practical Approach
    Publisher: CRC Press(Florida)
    Authors(s):

Journal Articles

  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Crystallisation and preliminary crystallographic studies of the copper binding domain of the amyloid recursor protein of Alzheimer's disease
    Year: 2005
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: F61
    Page numbers: 93-95
    Publisher: Blackwell Publishers(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 6
    Page numbers: 632-637
    Publisher: Blackwell Science Asia(Carlton)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metals and amyloid-Β in Alzheimer's disease
    Year: 2005
    Journal: International Journal of Experimental Pathology
    Volume: 86
    Issue: 3
    Page numbers: 147-159
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neuronal sorting protein-related sorLA/LR11 regulates processing of the amyloid precursor protein
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 38
    Page numbers: 13461-13466
    Publisher: National Academy of Sciences(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • SorLa/LR11, a neuronal sorting receptor that regulates processing of the amyloid precursor protein
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 38
    Page numbers: 13461-13466
    Publisher: National Academy of Sciences(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The amyloid precursor protein (APP) of Alzheimer disease and its paralog APLP2 modulate the Cu/Zn-NO catalyzed degradation of glypican-1 heparan sulfate in vivo
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 14
    Page numbers: 13913-13920
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Journal Articles

  • Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 50
    Page numbers: 51958-51964
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Year: 2004
    Journal: Molecular Brain Research
    Volume: 127
    Issue: 1-2
    Page numbers: 128-135
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cullular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Page numbers: 423-428
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Interaction of the molecular chaperone ΑB-crystallin with Α-synuclein: effects on amyloid fibril formation and chaperone activity
    Year: 2004
    Journal: Journal of Molecular Biology
    Volume: 340
    Page numbers: 1167-1183
    Publisher: Academic Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments
    Year: 2003
    Journal: Journal of Membrane Biology
    Volume: 193
    Issue: 1
    Page numbers: 35-45
    Publisher: Springer-Verlag, Journals(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cu2+-induced modification of the kinetics of Aβ(1-42) channels
    Year: 2003
    Journal: American Journal of Physiology - Cell Physiology
    Volume: 285
    Page numbers: C873-C880
    Publisher: American Physiological Society(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation
    Year: 2003
    Journal: Brain Research
    Volume: 966
    Page numbers: 231-244
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxicity from glutathione depletion is dependent on extracellular trace copper
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 71
    Page numbers: 889-897
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Selecting cells with different Alzheimer's disease γ-secretase activity using FACS: differential effect of presenilin exon 9 deletion on γ- and ε-cleavage
    Year: 2003
    Journal: European Journal of Biochemistry
    Volume: 270
    Page numbers: 495-506
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 19
    Page numbers: 17401-17407
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Book Chapters

  • Metals modulate the aggregation and neurotoxic properties of the prion peptide Prp106-126
    Year: 2002
    Book: Prion diseases and copper metabolism: BSE, scrapie and CJD research
    Publisher: Horwood Publishing(Chichester)
    Authors(s):

Journal Articles

  • Alternative transcripts of presenilin-I associated with frontotemporal dementia
    Year: 2002
    Journal: NeuroReport
    Volume: 13
    Issue: 5
    Page numbers: 917-921
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced prliferative response to CSF-1 (M-CSF)
    Year: 2002
    Journal: Brain Research
    Volume: 940
    Page numbers: 49-54
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein
    Year: 2002
    Journal: Journal of Neuroscience
    Volume: 22
    Issue: 2
    Page numbers: 365-376
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Evidence for a copper-binding superfamily of the amyloid precursor protein
    Year: 2002
    Journal: Biochemistry
    Volume: 41
    Page numbers: 9310-9320
    Publisher: American Chemical Society(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Aβ peptide
    Year: 2002
    Journal: Clinical and Experimental Immunology
    Volume: 129
    Page numbers: 453-463
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Metalloenzyme-like activity of Alzheimer's disease β-amyloid
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 40302-40308
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease
    Year: 2002
    Journal: Free Radical Biology and Medicine
    Volume: 33
    Issue: 1
    Page numbers: 45-51
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Prions in skeletal muscle
    Year: 2002
    Journal: Australian Veterinary Journal
    Volume: 80
    Issue: 8
    Page numbers: 484-485
    Publisher: Australian Veterinary Association(Brunswick)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2001

Book Chapters

  • Structural biology of prions
    Year: 2001
    Book: Prions. A challenge for science, medicine and public health system
    Publisher: S Karger AG(Basel)
    Authors(s):

Journal Articles

  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 1509-1520
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Interaction of linear homologous DNA duplexes via Holliday junction formation
    Year: 2001
    Journal: European Journal of Biochemistry
    Volume: 268
    Page numbers: 7-14
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation
    Year: 2001
    Journal: Journal of Neuroscience
    Volume: 21
    Issue: 15
    Page numbers: 5587-5596
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126
    Year: 2001
    Journal: Journal of Neuroscience Research
    Volume: 65
    Page numbers: 565-572
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
    Year: 2001
    Journal: Neurobiology of Disease
    Volume: 8
    Page numbers: 299-316
    Publisher: Academic Press(California)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from [gamma]-secretase
    Year: 2001
    Journal: European Journal of Biochemistry
    Volume: 268
    Page numbers: 5329-5336
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Variable phenotype of Alzheimer's disease with spastic paraparesis
    Year: 2001
    Journal: Annals of Neurology
    Volume: 49
    Issue: 1
    Page numbers: 125-129
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
top of page