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DR SPENCER WILLIAMS



Contact Details

Organization: Chemistry
Position: SENIOR LECTURER IN CHEMISTRY
Email:
Homepage: http://www.chemistry.unimelb.edu.au/staff/sjwill/research/
Work: (03)83442422
Fax: (03)93478124
Room: 532
Level: 05
Building: David Pennington Building
Campus: Parkville

Biography

Spencer Williams obtained his BSc and PhD (under the supervision of Professor Bob Stick) at the University of Western Australia (UWA). Following receipt of his PhD in 1998, he was an Izaac Walton Killam Postdoctoral Fellow in the laboratory of Professor Stephen G Withers at the University of British Columbia, Canada, where he worked on glycosidase inhibitors. In 2000 he moved to the USA where he was a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation in the laboratory of Professor Carolyn Bertozzi, based at the University of California, Berkeley. He joined the School of Chemistry at the University of Melbourne in 2002. His current interests include the application of chemical synthesis, and in particular carbohydrate chemistry, to biological problems, and the development of new therapeutic agents for treatment of cardiovascular disease, pain and fibrosis in the treatment of diabetes. He is a co-author of a textbook, Carbohydrates: The essential molecules of life (by RV Stick and SJ Williams, 2009, Elsevier). Curriculum vitae: BSc (Hons) W.Aust. (1995); PhD W.Aust. (conferred 2001); Izaac Walton Killam Postdoctoral Fellow, University of British Columbia (SG Withers, 1998-2000); Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation, University of California at Berkeley (CR Bertozzi, 2001-2002); Lecturer, University of Melbourne (2002); Selby Research Award (2002); RACI Divisional Organic Lectureship (2005); Senior Lecturer, University of Melbourne (2006); Dean�s Award for Excellence in Research (2007); Rennie Memorial Medal (2008).

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
medicinal chemistry treatments for cardiovascular disease and diabetes medicinal chemistry; organic chemistry Australia
Carbohydrate chemistry of pathogenic microorganisms including mycobacteria and leishmania carbohydrate chemistry; chemical biology Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) The University of Western Australia 31-Dec-1995
Doctor of Philosophy The University of Western Australia 10-Feb-2001

Memberships

Membership Type Membership Body Description Start Date End Date
Member International Carbohydrate Organization Australian Representative 01-Jul-2008
Member Royal Australian Chemical Institute Member 01-Jul-1994
Member Australian Society for Biochemistry and Molecular Biology Member 01-Jul-2004

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australian Chemical Institute (FRACI) 01-Sep-2009

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal Royal Australian Chemical Institute Rennie Memorial Medal (2008) 01-Oct-2008
Other (Award) University of Melbourne, Faculty of Science Dean's Award for Excellence in Research (2007) 01-Oct-2007
Other (Award) University of Melbourne, Faculty of Science Selby Research Award (2002) 01-Oct-2002

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Understanding and exploiting bacterial sulfatases Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Chemical tools for the study of mycobacterial glycolipid biosynthesis Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Synthesis of carbohydrate antigens and production of monoclonal antibodies for biotechnological applications Chief Investigator BIOSUPPLIES AUST PTY LTD,
AUST RESEARCH COUNCIL
Linkage Projects (AUST RESEARCH COUNCIL) 01/01/2005
Polysaccharide biosynthesis as a new drug target in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2006
Mannose metabolism in pathogenic microorganisms Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
X-ray Molecular Structure Elucidation Facility (MSEF) Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2007
Understanding the cardioprotective effects of flavonols Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
NEW FLAVONOLS TO TREAT CARDIOVASCULAR DISEASE Chief Investigator RMIT Development Grants (NHMRC) 01/01/2008
Novel metabolic enzyme in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2009
Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009
DEVELOPMENT OF NEW ANTI-FIBROTIC DRUGS FOR PREVENTION OF DIABETIC NEPHROPATHY Chief Investigator NHMRC Development Grants 01/01/2009

Contracts

Title Role Funding Source Award Date
Contract Synthesis of ionisable flavonols Chief Investigator NEUPROTECT PTY LTD 21/02/2005
SYNTHESIS OF WATER SOLUBLE FLAVONOLS Chief Investigator NEUPROTECT PTY LTD 01/11/2006

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Books

Book Chapters

  • Glycoconjugate Structure and Biosynthesis
    Year: 2009
    Book: Wiley Encyclopedia of Chemical Biology
    Publisher: John Wiley & Sons
    Authors(s):

Journal Articles

  • Aryl sulfamates are broad spectrum inactivators of sulfatases: Effects
    on sulfatases from various sources
    Year: 2009
    Journal: Bioorganic and Medicinal Chemistry Letters
    Volume: 19
    Page numbers: 477-480
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  • Non-volatile components of the essential oil secretory cavities of Eucalyptus
    leaves: Discovery of two glucose monoterpene esters, cuniloside B
    and froggattiside A
    Year: 2009
    Journal: Phytochemistry
    Volume: 70
    Page numbers: 1187-1194
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  • Robert Vyent Stick: A Colourful Character
    Year: 2009
    Journal: Australian Journal of Chemistry
    Volume: 62
    Page numbers: 503-509
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  • Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors
    Year: 2009
    Journal: Bioorganic and Medicinal Chemistry Letters
    Volume: 459-461
    Page numbers: 19
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  • Synthesis of Sulfated Glucosaminides for Profiling
    Substrate Specificities of Sulfatases and Fungal b-NAcetylhexosaminidases
    Year: 2009
    Journal: ChemBioChem
    Volume: 10
    Page numbers: 565-576
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Publications in 2008

Book Chapters

  • Anomeric anhydro sugars
    Year: 2008
    Book: Glycoscience. Chemistry and Chemical Biology
    Publisher: Springer(Berlin)
    Authors(s):
    Editors(s):

Journal Articles

  • “Click” preparation of carbohydrate 1-benzotriazoles, 1,4-disubstituted and 1,4,5-trisubstituted triazoles and their utility as glycosyl donors
    Year: 2008
    Journal: Australian Journal of Chemistry
    Volume: 61
    Page numbers: 837-846
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  • 'Click' cycloaddition catalysts: Copper(I) and copper(II) tris(triazolylmethyl)amine complexes
    Year: 2008
    Journal: Chemical Communications
    Volume: -
    Page numbers: 2459-2461
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  • Direct Evidence for ArO-S Bond Cleavage upon
    Inactivation of Pseudomonas aeruginosa Arylsulfatase by
    Aryl Sulfamates
    Year: 2008
    Journal: ChemBioChem
    Volume: 9
    Page numbers: 613-623
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  • Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates
    Year: 2008
    Journal: ChemBioChem
    Volume: 9
    Issue: 4
    Page numbers: 613-623
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com/journal/117915906/abstract?CRETRY=1&SRETRY=0
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  • Discovery of Water-Soluble Antioxidant Flavonols without
    Vasorelaxant Activity
    Year: 2008
    Journal: ChemMedChem: chemistry enabling drug discovery
    Volume: 3
    Page numbers: 1572-1579
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  • Sulfotransferases, sulfatases and formylglycine-generating
    enzymes: a sulfation fascination
    Year: 2008
    Journal: Current Opinion in Chemical Biology
    Volume: 12
    Page numbers: 573-581
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  • Understanding the cardioprotective effects of flavonols: Discovery of relaxant flavonols without antioxidant activity
    Year: 2008
    Journal: Journal of Medicinal Chemistry
    Volume: 51
    Page numbers: 1874-1884
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Publications in 2007

Book Chapters

  • Complex carbohydrate-modifying enzymes
    Year: 2007
    Book: Glycobiology
    Publisher: Scion Publishing(Bloxham)
    Authors(s):

Journal Articles

  • Electronic Structure of the Sulfonyl and Phosphonyl Groups:
    A Computational and Crystallographic Study
    Year: 2007
    Journal: Inorganic Chemistry
    Volume: 46
    Page numbers: 8871-8886
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  • Galactose-based phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria
    Year: 2007
    Journal: Organic & Biomolecular Chemistry
    Volume: 5
    Page numbers: 952-959
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  • Transition-state mimicry by glycosidase inhibitors: A critical kinetic analysis
    Year: 2007
    Journal: Journal of the American Chemical Society
    Volume: 129
    Page numbers: 4530-4531
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  • Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant
    Year: 2007
    Journal: Journal of Medical Microbiology
    Volume: 56
    Page numbers: 454-458
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Publications in 2006

Journal Articles

  • 5'-Adenosinephosphosulfate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice
    Year: 2006
    Journal: Molecular Microbiology
    Volume: 59
    Issue: 6
    Page numbers: 1744
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  • Ground state structures of sulfate monoesters and sulfamates reveal reveal similar reaction coordinates for sulfuryl and sulfamyl transfer


    Year: 2006
    Journal: Chemical Communications
    Volume: -
    Page numbers: 314-316
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  • A convenient gram-scale synthesis of uridine diphosphol(13C6) glucose
    Year: 2006
    Journal: Carbohydrate Research
    Volume: 33341
    Page numbers: 1743-1747
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  • Leishmania β-1,2-mannan is assembled on a mannose-cyclic phosphate primer
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 25
    Page numbers: 9458-9463
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  • Synthesis and testing of mechanism-based protein-profiling probes for retaining endo-glycosidases
    Year: 2006
    Journal: ChemBioChem
    Volume: 7
    Page numbers: 116-124
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  • Use of Click Chemistry to Define the Substrate Specificity of Leishmania -1,2-Mannosyltransferases
    Year: 2006
    Journal: ChemBioChem
    Volume: 7
    Issue: 9
    Page numbers: 1384 - 1391
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com/cgi-bin/abstract/112702656/ABSTRACT
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Publications in 2005

Journal Articles

  • Active-site peptide "finger-printing" of glycosidases in complex mixtures by mass spectrometry
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 42
    Page numbers: 35126-35135
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  • Compartmentalization of Lipid Biosynthysis in Mycobacteria
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 22
    Page numbers: 21645-21652
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  • Rapid, iterative assembly of octyl ?-1,6-oligomannosides and their 6-deoxy equivalents
    Year: 2005
    Journal: Organic & Biomolecular Chemistry
    Volume: 3
    Page numbers: 1982-1992
    Publisher: Royal Society of Chemistry(Cambridge)
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Major Reference Works

  • First Update:Handbook of Reagents for Organic Synthesis: Reagents for glycoside, nucleotide and peptide synthesis
    Year: 2005
    Reference Work Title: First Update
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Author(s):

Publications in 2004

Journal Articles

  • A master of its sulfate
    Year: 2004
    Journal: Nature Structural and Molecular Biology
    Volume: 11
    Issue: 8
    Page numbers: 686-687
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  • Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A
    Year: 2004
    Journal: Chemical Communications
    Volume: 2004
    Issue: 16
    Page numbers: 1794-1795
    Publisher: Royal Society of Chemistry(Cambridge)
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  • Trehalose is required for growth of Mycobacterium smegmatis
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 28
    Page numbers: 28835-28843
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Publications in 2003

Journal Articles

  • A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer
    Year: 2003
    Journal: Chemical Communications
    Volume: 2003
    Issue: 8
    Page numbers: 944-945
    Publisher: Royal Society of Chemistry(Cambridge)
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  • Novel microsomal triglyceride transfer protein inhibitors
    Year: 2003
    Journal: Expert Opinion on Therapeutic Patents
    Volume: 13
    Issue: 4
    Page numbers: 479-488
    Publisher: Ashley Publications(London)
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Publications in 2002

Journal Articles

  • 5'-Adenosinephosphosulfate lies at a metabolic branchpoint in mycobacteria
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 36
    Page numbers: 32606-32615
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  • Aspartate 313 in the Streptomyces plicatus Hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 42
    Page numbers: 40055-40065
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  • Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach
    Year: 2002
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 99
    Issue: 26
    Page numbers: 17037-17042
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  • Glycosynthases: Mutant glycosidases for glycoside synthesis
    Year: 2002
    Journal: Australian Journal of Chemistry
    Volume: 55
    Page numbers: 3-12
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  • High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding
    Year: 2002
    Journal: Biochemistry
    Volume: 41
    Page numbers: 4246-4254
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  • sulfotransferases and sulfatases in mycobacteria
    Year: 2002
    Journal: Chemistry & Biology
    Volume: 9
    Page numbers: 767-776
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Publications in 2001

Book Chapters

  • Anomeric anhydro sugars
    Year: 2001
    Book: Glycoscience: Chemistry and Chemical Biology
    Publisher: Springer-Verlag Heidelberg(Heidelberg)
    Authors(s):

Journal Articles

  • Protein-carbohydrate interactions: learning lessons from nature
    Year: 2001
    Journal: Trends in Biotechnology
    Volume: 19
    Issue: 9
    Page numbers: 356-362
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