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DR NICOLE LOUISE LA GRUTA



Contact Details

Organization: Microbiology and Immunology
Position: SENIOR RESEARCH OFFICER
Email:
Work: 8344 3384
Room: 3.18
Level: 03
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
CD8+ T cells, influenza Australia

International Linkages

Country Establishment Collaboration
United States St Judes Children's Research Hospital Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) Monash University 31-Dec-1995
Doctor of Philosophy Monash University 31-Dec-2000

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Society for Immunology 20-Oct-2005

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Monash University 20-Oct-1999
Scholarship Federal Government Postgraduate Award 01-Mar-1996
Scholarship Monash University Gastric Biology scholarship 01-Sep-1999

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
THE ROLE OF T CELL RECEPTOR AVIDITY IN DETERMINING T CELL REPERTOIRES AND RESPONSES Chief Investigator NHMRC Project Grants 01/01/2005
Determinants of virus specific CD8+ T cell hierarchies. Chief Investigator NHMRC Project Grants 01/01/2007
R. DOUGLAS WRIGHT BIOMEDICAL CAREER DEVELOPMENT AWARD - (THE ROLE OF ANTIGEN DOSE AND T CELL REPERTOIRE IN DETERMINING CD8+ T CELL IMMUNODOMINANCE HIERARCHIES) Chief Investigator NHMRC Career Development Awards 01/01/2007
INVESTIGATING THE ROLE OF TCR AVIDITY IN INFLUENZA VIRUS-SPECIFIC CD8 T CELL RESPONSES Principal Supervisor NHMRC Scholarships 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 9
    Page numbers: 3351-3356
    Author(s):
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  • Cell Cycle-Related Acquisition of Cytotoxic Mediators Defines the Progressive Differentiation to Effector Status for Virus-Specific CD8+ T Cells
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Page numbers: 3818-3822
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  • Epitope-specific TCRß repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 6
    Page numbers: 2034-2039
    Author(s):
    URL - restricted access http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18238896
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  • Killer T cells in influenza
    Year: 2008
    Journal: Pharmacology and Therapeutics
    Volume: 120
    Page numbers: 186-196
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  • Terminal Deoxynucleotidyltransferase Is Required for the Establishment of Private Virus-Specific CD8+ TCR Repertoires and Facilitates Optimal CTL Responses
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Page numbers: 2556-2562
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  • Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
    Year: 2008
    Journal: Molecular Microbiology
    Volume: 45
    Page numbers: 607-18
    Author(s):
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Conference Publications/Papers

  • How the structure of viral peptide-MHC complexes influences cytotoxic T cell immunity to viral infections
    Year: 2008
    Event name: Immunobiology of Influenza Virus Infections: Approaches for an Emerging Zoonotic Disease
    Conference Publication: Immunology of Influenza Infection: Approaches for an emerging zoonotic disease 2008
    Page numbers: 33-45
    Publisher: Research Signpost(Trivandrum)
    Author(s):

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 11
    Page numbers: 2951-2959
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  • A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 4
    Page numbers: 994-999
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  • Establishment and recall of CD8+ T-cell memory in a model of localized transient infection
    Year: 2006
    Journal: Immunological Reviews
    Volume: 211
    Issue: 1
    Page numbers: 133-145
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Publications in 2005

Journal Articles

  • Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 32
    Page numbers: 11432-11437
    Publisher: National Academy of Sciences(Washington DC)
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  • Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130
    Year: 2005
    Journal: Gastroenterology
    Volume: 129
    Page numbers: 1005-1018
    Publisher: WB Saunders Co(Pennsylvania)
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  • Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 17
    Page numbers: 6074-6079
    Publisher: National Academy of Sciences(Washington DC)
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  • Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 4
    Page numbers: 382-389
    Publisher: Nature America(New York)
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Publications in 2004

Journal Articles

  • Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection
    Year: 2004
    Journal: Science
    Volume: 16
    Issue: 3
    Page numbers: 179-184
    Publisher: American Society for the Advancement of Science(Washington DC)
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  • Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 10
    Page numbers: 3545-3550
    Publisher: National Academy of Sciences(Washington DC)
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  • Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T cell responses: Correlation of Cytokine Profile and TCR Avidity1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 5553-5560
    Publisher: American Association of Immunologists(Maryland)
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  • Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Issue: 10
    Page numbers: 5994-6002
    Publisher: American Association of Immunologists(Maryland)
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