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DR DEBORAH TEW



Contact Details

Organization: Pathology
Position: RESEARCH ASSISTANT
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/barnham/
Work: 03 83442558
Fax: 03 934767750

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
neurodegenerative diseases, protein misfolding diseases alzheimers disease, parkinsons disease, CJD Australia

International Linkages

Country Establishment Collaboration
United Kingdom Daresbury Synchrotron Radiation Source Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 31-Dec-1974
Bachelor of Science (honours) Monash University 31-Dec-1978
Graduate Diploma in Education Monash University 31-Dec-1975
Doctor of Philosophy Monash University 06-Dec-2002

Memberships

Membership Type Membership Body Description Start Date End Date
Member ASBMB ordinary member 06-Feb-1004

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Probing secondary conformation of amyloid beta using Synchrotron Radiation Circular Dichroism (SRCD) Chief Investigator ANSTO Major Res Facilities 26/11/2004
CHARACTERISATION OF WILD-TYPE AND FAMILIAL MUTANTS OF AMYLOID BETA Chief Investigator ALZHEIMER'S AUST RESEARCH LTD Research Grant 01/11/2005
Probing Secondary Conformation of Alpha Synuclein using Synchrotron Radiation Circular Dichroism Chief Investigator ANSTO Major Res Facilities 28/11/2005

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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Publications in 2008

Journal Articles

  • Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity


    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 46
    Page numbers: 11950-11958
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  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Cu2+ Binding Modes of Recombinant α-Synuclein – Insights from EPR Spectroscopy
    Year: 2008
    Journal: Journal of the American Chemical Society
    Volume: 130
    Issue: 24
    Page numbers: 7766-7773
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  • Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Issue: 5
    Page numbers: 1425-1434
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  • Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer’s Disease Amyloid-β Peptide
    Year: 2008
    Journal: Biophysical Journal
    Volume: 94
    Page numbers: 2752-2766
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Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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Publications in 2006

Journal Articles

  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
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  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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Publications in 2005

Journal Articles

  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2004

Journal Articles

  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2003

Journal Articles

  • Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments
    Year: 2003
    Journal: Journal of Membrane Biology
    Volume: 193
    Issue: 1
    Page numbers: 35-45
    Publisher: Springer-Verlag, Journals(New York)
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  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
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