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PROF ELIZABETH HARTLAND

Positions

Academic, Microbiology and Immunology

Publications

Selected publications

2012
- Journal Articles Refereed
  - A method for quantifying pulmonary Legionella pneumophila infection in mouse lungs by flow cytometry. BMC Research Notes. 5. 2012
  - Discovery of an archetypal protein trasport system in bacterial outer membranes. Nature Structural and Molecular Biology. 19:506-510. 2012
  - Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection. PLoS Pathogens. 8:1-13. 2012
2011
- Journal Articles Refereed
  - A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-kappa B for degradation. Molecular Microbiology. 80:219-230. 2011
  - Enteropathogenic and Enterohemorrhagic Escherichia coli Type III Secretion Effector EspV Induces Radical Morphological Changes in Eukaryotic Cells. Infection and Immunity. 79:1067-1076. 2011
  - Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements. Molecular Microbiology. 80:1420-1438. 2011
  - EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function. Cellular Microbiology. 13:1429-1439. 2011
  - Immune control of Legionella infection: an in vivo perspective. Frontiers in Microbiology. 2:1-6. 2011
- Journal Articles Unrefereed
  - Sculpting the immune response to infection. Nature Immunology. 12:579-582. 2011
2010
- Journal Articles Refereed
  - Legionella pneumophila Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins. Journal of Bacteriology. 192:6001-6016. 2010
  - Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease. PLoS Genetics. 6:1-15. 2010
  - Binding to Na+/H+ exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH. Cellular Microbiology. 12:1718-1731. 2010
  - Crystal Structure of a Legionella pneumophila Ecto-Triphosphate Diphosphohydrolase, A Structural and Functional Homolog of the Eukaryotic NTPDases. Structure. 18:228-238. 2010
  - Cutting edge: pulmonary Legionella pneumophila is controlled by plasmacytoid dendritic cells but not type I IFN. Journal of Immunology. 184:5429-5433. 2010
  - Molecular Pathogenesis of Infections Caused by Legionella pneumophila. Clinical Microbiology Reviews. 23:274-298. 2010
  - Molecular detection of Legionella: moving on from mip. Frontiers in Microbiology. 1:1-5. 2010
  - The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. Cellular Microbiology. 12:1272-1291. 2010
  - The Type III Effectors NIeE and NIeB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65. PLoS Pathogens. 6:e1000898-e1000898. 2010
  - The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cellular Microbiology. 12:626-639. 2010
  - Two Novel Point Mutations in Clinical staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection. PLoS Pathogens. 6. 2010
  - Virulence regulation in Citrobacter rodentium: the art of timing. Microbial Biotechnology. 3:259-268. 2010
- Other Refereed Contribution to Refereed Journals
  - Update on Legionnaires' disease: pathogenesis, epidemiology, detection and control. Molecular Microbiology. 76:1-11. 2010
2009
- Journal Articles Refereed
  - Characterisation of atypical enteropathogenic E. coli strains of clinical origin. BMC Microbiology. 9:1-10. 2009
  - Contribution of the pst-phoU Operon to Cell Adherence by Atypical Enteropathogenic Escherichia coli and the Virulence of Citrobacter rodentium. Infection and Immunity. 77:1936-1944. 2009
  - Experimental Legionella longbeachae infection in intratracheally inoculated mice. Journal of Medical Microbiology. 58:723-730. 2009
  - Infections caused by nonpneumophila species of Legionella. Reviews in Medical Microbiology. 20:1-11. 2009
  - Rabbit-specific fimbriae, Ral, alter the patterns of in vitro adherence and intestinal colonisation of rabbits by human-specific enteropathogenic E. coli.. Microbes and Infection. 11:803-810. 2009
  - Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli. BMC Microbiology. 9:30-39. 2009
  - ShigaToxin-producing Escherichia coli strains negative for locus of enterocyte effacement.. Emerging Infectious Diseases. 15:372-380. 2009
2008
- Journal Articles Refereed
  - A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium. Cellular Microbiology. 10:499-513. 2008
  - Bicarbonate-mediated transcriptional activation of divergent operons by the virulence regulatory protein, RegA, from Citrobacter rodentium. Molecular Microbiology. 68:314-327. 2008
  - Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila : substrate specificity and requirement for virulence. Journal of Biological Chemistry. 283:12909-12918. 2008
  - Influence of Gastric Acid on Susceptibility to Infection with Ingested Bacterial Pathogens. Infection and Immunity. 76:639-645. 2008
  - Possible effects of microbial ecto-nucleoside triphosphate diphosphohydrolases on host-pathogen interactions.. Microbiology and Molecular Biology Reviews. 72:765-781. 2008
  - RegA, an AraC-Like Protein, Is a Global Transciptional Regulator That Controls Virulence Gene Expression in Citrobacter rodentium. Infection and Immunity. 76:5247-5256. 2008
  - Significant role for ladC in initiation of Legionella pneumophila infection. Infection and Immunity. 76:3075-3085. 2008
  - Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections. Vaccine. 26:5649-5653. 2008
  - The Major Surface-Associated Saccharides of Klebsiella pneumoniae Contribute to Host Cell Association.. PLoS One. 3:1-10. 2008
  - The NleE/OspZ family of effector proteins is required for polymorphonuclear transepithelial migration, a characteristic shared by enteropathogenic Escherichia coli and Shigella flexneri infections. Infection and Immunity. 76:369-379. 2008
- Other Refereed Contribution to Refereed Journals
  - Bacterial protein secretion and trafficking down under. Annual Scientific Meeting of the Australian Society for Microbiology, 6-10 July 2008, Melbourne Convention Center, Victoria, Australia. Future Microbiology. 3:489-491. 2008
2007
- Journal Articles Refereed
  - A Common fold Mediates Vertebrate Defense and Bacterial Attack. Science. 317:1548-1551. 2007
  - A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila. Cellular Microbiology. 9:1922-1935. 2007
  - Contribution of a Novel Gene, rpeA , Encoding a Putative Autotransporter Adhesin to Intestinal Colonization by Rabbit-Specific Enteropathogenic Escherichia coli. Infection and Immunity. 75:4664-4669. 2007
  - Secondary Acylation of Klebsiella pneumoniae Lipopolysaccharide Contributes to Sensitivity to Antibacterial Peptides. Journal of Biological Chemistry. 282:15569-15577. 2007
  - Sel1 Repeat Protein LpnE Is a Legionella pnuemophila Virulence Determinant That Influences Vacuolar Trafficking. Infection and Immunity. 75:5575-5585. 2007
  - The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. Cell Host & Microbe. 2:160-171. 2007
2006
- Journal Articles Refereed
  - Contribution of FliC to Epithelial Cell Invasion by Enterohemorrhagic Escherichia coli O113:H21. Infection and Immunity. 74:6999-7004. 2006
  - Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium. Infection and Immunity. 74:2328-2337. 2006
  - Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry. Infection and Immunity. 74:1683-1691. 2006
2005
- Research Book Chapters
  - Tissue tropism in intestinal colonization. Colonization of mucosal surfaces. ASM Press. 237-251. 2005
- Journal Articles Refereed
  - Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens. Infection and Immunity. 73:8411-8417. 2005
  - Invasion of Epithelial Cells by Locus of Enterocyte Effacement-Negative Enterohemorrhagic Escherichia Coli. Infection and Immunity. 73:3063-3071. 2005
2004
- Journal Articles Refereed
  - Contribution of Long Polar Fimbriae to the Virulence of Rabbit-Specific Enteropathogenic Escherichia coli. Infection and Immunity. 72:1230-1239. 2004
2003
- Research Book Chapters
  - Yersinia Species. International Handbook of Foodborne Pathogens. Dekker - Marcel Dekker. 323-355. 2003
- Journal Articles Refereed
  - Contribution of Efa1/LifA to the adherence of enteropathogenic Escherichia coli to epithelial cells. Microbial Pathogenesis. 34:205-215. 2003
  - Prevalence of the lpfO113 gene cluster among Escherichia coli O157 and O26 strains isolated from different sources. Veterinary Microbiology. 96:259-266. 2003
2002
- Journal Articles Refereed
  - Intimin types influence the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157:H7. Gut. 50:180-185. 2002
2001
- Journal Articles Refereed
  - Immune Response to Infection with Mycobacterium ulcerans. Infection and Immunity. 69:1704-1707. 2001
  - The coiled-coil domain of enteropathogenic E. coli type III secreted protein is involved in EspA filament-mediated cell attachment and haemolysis. Infection and Immunity. 69:4055-4064. 2001

Research

Investigator on

Contract
- FIGHTING INFECTION: EXPLOITING HOST-PATHOGEN INTERACTIONS (Program Grants) awarded by MONASH UNIVERSITY 2011 - 2015
- SUSCEPTIBILITY OF GPR43 KNOCKOUT MICE TO INFECTION awarded by GARVAN INSTITUTE OF MEDICAL RESEARCH 2010 -
- MICROBIAL AND CELLULAR IMAGING AND ANALYSIS FACILITY (Linkage Infrastructure (Equipment and Facilities)) awarded by UNIVERSITY OF TECHNOLOGY SYDNEY 2009 - 2011
- THE ROLE OF CD39 IN LUNG DISEASE awarded by ST VINCENTS HEALTH 2009 -
- THE ROLE OF CD73 IN LUNG DISEASE awarded by OKLAHOMA MEDICAL RESEARCH FOUNDATION 2009 -
- THE ROLE OF REGULATORY T CELLS IN BACTERIAL DISEASE awarded by TECHNISCHE UNIVERSITAET MUENCHEN (TUM) 2009 -
Grant
- Biology and evolution of intracellular parasitism (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2013 - 2015
- Death receptor signaling during E. coli and Salmonella infection (Project Grants) awarded by NHMRC 2013 - 2015
- AUSTRALIAN CENTRE FOR HEPATITIS AND HIV VIROLOGY RESEARCH (ACH2) - EXTENSION (Commonwealth AIDS Research Grants) awarded by DEPT OF HEALTH & AGEING 2011 - 2013
- AUSTRALIAN CENTRE FOR HEPATITIS AND HIV VIROLOGY RESEARCH (ACH2) - EXTENSION (Commonwealth AIDS Research Grants) awarded by DEPT OF HEALTH & AGEING 2011 - 2013
- DEATH RECEPTOR SIGNALING DURING E. COLI AND SALMONELLA INFECTION (Melbourne Research Grants Support Scheme) awarded by UNIVERSITY OF MELBOURNE 2011 -
- The biology, structure and function of bacterial virulence effectors (Future Fellowships) awarded by AUST RESEARCH COUNCIL 2009 - 2013
- How bacteria cause diarrhoea (Project Grants) awarded by NHMRC 2009 - 2011
- How bacteria grow in the gut (Project Grants) awarded by NHMRC 2009 - 2011
- How bacteria live inside human cells (Project Grants) awarded by NHMRC 2009 - 2011
- How pathogenic bacteria sense and respond to the varied environments they encounter in their hosts' tissues (Project Grants) awarded by NHMRC 2009 - 2011
- Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009
- A NOVEL CD39-LIKE ECTO-NTPDASE OF LEGIONELLA PNEUMOPHILA (Project Grants) awarded by NHMRC 2007 - 2009
- HOST CELL TARGETS OF BACTERIAL VIRULENCE EFFECTORS (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2007 - 2009
- A HIGH-THOUGHPUT SCREENING AND SEQUENCING FACILITY FOR SINGLE CELL GENOMICS (Linkage Infrastructure (Equipment and Facilities)) awarded by UNIVERSITY OF QUEENSLAND - 2012
- RAPID ENVIRONMENTAL DETECTION OF LEGIONELLA (Interdisciplinary Seed Grants) awarded by UNIVERSITY OF MELBOURNE

Awards

Education and training

GRAD DIP IN HIGHER ED, Monash University 2004
BA, University of Melbourne 1997
PHD, University of Melbourne 1996
BA SCN, University of Melbourne 1990
B.SC, University of Melbourne 1987

Supervision

Available for supervision

Y

Contact Details
- hartland@unimelb.edu.au
- 8344 8041
- Location
  - Level: 04 Room: 4.04B, Microbiology Building, Parkville
Graduate Study
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