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DR LARS KJER-NIELSEN

Positions

Academic, Microbiology and Immunology

Structural Immunology (MHC; T cell receptors)

Overview

Has subject area

For 2008 6 Digit Code
- Immunology not elsewhere classified
Seo 2008 6 Digit Code
- Immune System and Allergy

Publications

Selected publications

2012
- Journal Articles Refereed
  - A Structural Basis for Varied αβ TCR Usage against an Immunodominant EBV Antigen Restricted to a HLA-B8 Molecule. Journal of Immunology. 188:311-321. 2012
  - Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature. 486:554-558. 2012
  - MR1 presents microbial vitamin B metabolites to MAIT cells. Nature. 491:717-723. 2012
  - Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. Journal of Experimental Medicine. 209:761-774. 2012
2011
- Journal Articles Refereed
  - A semi-invariant V_α 10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nature Immunology. 12:616-625. 2011
  - Antigen-Driven Patterns of TCR Bias Are Shared across Diverse Outcomes of Human Hepatitis C Virus Infection. Journal of Immunology. 186:901-912. 2011
  - Atypical T cell receptor usage defines a population of Natural Killer T cells with distinct glycolipid antigen recognition properties. Journal of Immunology. 186:160.13-160.13. 2011
  - Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity. Tissue Antigens. 78:11-20. 2011
  - The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotype family. Haematologica. 96:110-118. 2011
2010
- Research Book Chapters
  - HLA Molecules of the Major Histocompatibility Complex. The HLA Complex in Biology and Medicine A resource Book. Jaypee Brothers. 86-118. 2010
- Journal Articles Refereed
  - Allelic polymorphism in the T cell receptor and its impact on immune responses. Journal of Experimental Medicine. 207:1555-1567. 2010
  - Antigen recognition by CD1d-restricted NKT T cell receptors. Seminars in Immunology. 22:61-67. 2010
  - Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of the United States of America. 107:10608-10613. 2010
  - The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide. Journal of Molecular Biology. 397:467-480. 2010
  - The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature. 467:844-848. 2010
2009
- Journal Articles Refereed
  - Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO Journal. 28:3781-3793. 2009
  - Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor. Immunity. 777-788. 2009
  - Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors. Immunity. 31:47-59. 2009
  - T Cell Allorecognition via Molecular Mimicry. Immunity. 31:897-908. 2009
  - T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell Repertoire. Immunity. 31:60-71. 2009
  - The shaping of T cell receptor recognition by self-tolerance. Immunity. 30:193-203. 2009
2008
- Journal Articles Refereed
  - A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. Journal of Experimental Medicine. 205:939-949. 2008
  - Human Leukocyte Antigen Class I-Restricted Activation of CD8⁺ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity. Immunity. 28:822-832. 2008
  - T cell allorecognition and MHC restriction-A case of Jekyll and Hyde?. Molecular Immunology. 45:583-598. 2008
  - T-cell receptor bias and immunity. Current Opinion in Immunology. 20:119-25. 2008
2007
- Journal Articles Refereed
  - A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nature Immunology. 8:268-276. 2007
  - CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.. Nature. 448:44-49. 2007
  - Structural Insight into Natural Killer T Cell Receptor Recognition of CD1d. Advances in Experimental Medicine and Biology. 598:20-34. 2007
  - Structural Studies on HLA-G: Implications for Ligand and Receptor. Human Immunology. 68:220-226. 2007
2006
- Journal Articles Refereed
  - A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. Journal of Experimental Medicine. 203:661-673. 2006
  - Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry. Journal of Biological Chemistry. 45:34324-34332. 2006
  - Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction. Proceedings of the National Academy of Sciences of the United States of America. 103:6641-6646. 2006
  - Structural basis for a major histocompatability complex class 1b-restricted T cell response. Nature Immunology. 7:256-264. 2006
  - TCRα Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-bound Viral Epitope. Journal of Immunology. 177:6804-6814. 2006
  - The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.. Acta Crystallographica Section F - Structural Biology and Crystallization Communications. 62:70-73. 2006
2005
- Journal Articles Refereed
  - Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection¹. Journal of Immunology. 174:5593-5601. 2005
  - CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection¹. Journal of Immunology. 175:3826-3834. 2005
  - High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I. Implications for T-cell Receptor Engagement and T-cell Immunodominance. Journal of Biological Chemistry. 280:23900-23909. 2005
  - Structural studies on the alphabeta T-cell receptor. IUBMB Life. 57:575-582. 2005
  - T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nature Immunology. 6:1114-1122. 2005
  - The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nature Immunology. 6:171-180. 2005
  - The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. Journal of Experimental Medicine. 202:1249-1260. 2005
- Conference Proceedings
  - A Super-Bulged Epitope and Single Amino Acid Polymorphism Identify Critical Features for T Cell Recognition. 571-571. 2005
  - Recognition of the Non-Classical MHC Class I Molecule, HLA-E, by the Adaptive Immune System. 443-443. 2005
2004
- Journal Articles Refereed
  - Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3. Proceedings of the National Academy of Sciences of the United States of America. 101:7675-7680. 2004
  - Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue. Journal of Biological Chemistry. 279:23438-23446. 2004
  - Identification of a Golgi-localised GRIP domain protein from Arabidopsis thaliana. Planta. 219:1050-1056. 2004
  - Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine. 200:13-24. 2004
  - The Structure of H-2K^b and K^bm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance^1,2. Journal of Immunology. 173:402-409. 2004
  - The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody . Acta Crystallographica Section D - Biological Crystallography. D60:1425-1428. 2004
2003
- Journal Articles Refereed
  - A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition. Journal of Experimental Medicine. 198:679-691. 2003
  - A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity . Immunity. 18:53-64. 2003
  - Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens. 62:408-417. 2003
2002
- Journal Articles Refereed
  - Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Letters. 527:27-32. 2002
  - The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance. Structure. 10:1521-1532. 2002
  - The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization¹. Journal of Immunology. 169:5153-5160. 2002
  - The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.. Acta Crystallographica Section D - Biological Crystallography. 58:2131-2134. 2002

Research

Investigator on

Contract
- MICROBIAL GENETICS IN IMMUNE ACTIVATION awarded by NATIONAL INSTITUTE OF GENETICS 2012 -
Grant
- NKT cell receptors (Project Grants) awarded by NHMRC 2009 - 2011

Awards

Education and training

PhD, Monash University 1990
BVSc, University of Melbourne 1984

Supervision

Available for supervision

Y

Contact Details
- lkn@unimelb.edu.au
- 83449914
- fax: 93471540
- Location
  - Level: 05 Room: 09, Microbiology Building, Parkville
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