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DR TOBIAS MERSON

Positions

Affiliation

Member of

  • International Society for Stem Cell Research. Associate Member 2006 -
  • Australian Society for Medical Research. Member 2005 -
  • Society for Neuroscience. Member 2004 -
  • Australian Neuroscience Society. Member 2002 -

Publications

Selected publications

Research

Investigator on

Additional Grant Information

  • 2006: Awarded MSRA Betty Cuthbert Fellowship. 20010-12: NHMRC Project Grant   

Awards

Education and training

  • PhD, University of Melbourne 2006
  • BSc(Hons), The University of Queensland 1999
  • BA, The University of Queensland 1998

Awards and honors

  • NHMRC Fellowship, 2007
  • Serono Australia Travel Award, 2006

Supervision

Available for supervision

  • Y

Supervision Statement

  • Recent highlights from the laboratory:
    • We have generated genetically modified mice to specifically deplete oligodendrocytes from the brain in a highly specific manner. Neuronal function is dramatically affected by oligodendrocyte depletion well before myelin is lost from axons. This has implications for understanding the function of oligodendrocytes and the role of functionally inert myelin in disease
    • We have demonstrated that adult neural stem/progenitor cells play a major role in the regeneration of oligodendrocytes and myelin following the death of these cells. This research could translate to novel stem cell based therapies for Multiple Sclerosis and other myelin pathologies
    • Our analysis of oligodendrocyte organisation in the brain is revealing fascinating new information about oligodendrocyte topography in white matter. The work has important implications for understanding how specific patterns of myelination restore neuronal function after injury and contribute to brain plasticity in adult life.

    Projects available:
    1. Role of alternate energy sources in overcoming oligodendrocyte dysfunction
    2. Neural stem cell responses to close versus distant oligodendrocyte loss
    3. Characterising oligodendrocyte and myelin organisation in the brain after social and/or sensory deprivation