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PROF Arthur SHULKES
Positions
- Academic, Medicine, Dentistry and Health Sciences
- Role of regulatory peptides in peptic ulcer disease, stomach and colon cancers and obesity
Overview
Affiliation
Member of
- International Regulatory Peptides Society. Member 2008 -
- American Physiological Society. Member 1996 -
- National Association of Research Fellows of the NHMRC. President 1994-95 1988 -
- American Gastroenterological Association. AGA Fellow 1978 -
- Gastroenterological Society of Australia. (Councillor 1996 - 99, Research Institute Chair 1996 - 99, Member 1989 - 95, Member Scientific Program Committee 1990-95, Chair IT Committee 1998-99 1978 -
- Melbourne University Staff Association. Member 1975 -
- National Tertiary Education Union. Member of Research Committee 2002-04 1975 -
- Australian Physiological and Pharmacological Society. Member 1970 -
- Australian Society for Medical Research. Member 1970 -
- Endocrine Society of Australia. Member 1970 -
- International Steering Committee of the Symposium on Regulatory Peptides. Member 1996-2000, Chair 2000-2004 1996 - 2004
Publications
Selected publications
2012
Journal Articles Refereed
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P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth
. Cancer Letters. 317:65-71. 2012 - A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps. Cancer prevention research. 5:675-684. 2012
- Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo. Biochemical Pharmacology. 83:524-530. 2012
- Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut. 61:774-776. 2012
- Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF). Endocrinology. 153:3006-3016. 2012
- The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity. Diabetes. 61:1122-1132. 2012
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2011
Journal Articles Refereed
- Ferric ions inhibit proteolytic processing of progastrin. Biochemical and Biophysical Research Communications. 404:1083-1087. 2011
- Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency. Endocrinology. 152:3062-3073. 2011
- In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 300:G334-G344. 2011
- Long-Term Persistence of Hormonal Adaptations to Weight Loss. New England Journal of Medicine. 365:1597-1604. 2011
- P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth. Cancer Letters. 317:65-71. 2011
- Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo. Endocrinology. 153:1082-1092. 2011
Other Refereed Contribution to Refereed Journals
- Long-Term Persistence of Hormonal Adaptations to Weight Loss EDITORIAL COMMENT. New England Journal of Medicine. 365:1597-1604. 2011
2010
Journal Articles Refereed
- Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family. Current Opinion in Endocrinology, Diabetes and Obesity. 17:77-88. 2010
- Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor. FEBS Letters. 584:4413-4418. 2010
- Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP(1-46)), the primary GRP gene-derived peptide product of the pregnant ovine endometrium. Peptides. 31:284-290. 2010
- Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion. Proceedings of the National Academy of Sciences of the United States of America. 107:17397-17402. 2010
- Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine. American Journal of Physiology - Gastrointestinal and Liver Physiology. 299:G22-G227. 2010
- The C-terminal flanking peptide (CTFP) progastrin inhibits apoptosis via a P13-kinase-dependent pathway. Regulatory Peptides. 165:224-231. 2010
2009
Journal Articles Refereed
- Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth. Biochimica et Biophysica Acta - Molecular Cell Research. 1793:477-488. 2009
- Gastrin-releasing peptide: Different forms, different functions. BioFactors: vitamins - autoregulatory substances - trace elements - growth factors. 35:69-75. 2009
- Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation and colorectal cancer in mice. Journal of Clinical Investigation. 119:2691-2701. 2009
- Peptide processing and biology in human disease. Current Opinion in Endocrinology, Diabetes and Obesity. 16:79-85. 2009
2008
Book Chapters Other
- Gastrin-releasing peptide. Encyclopedia of Cancer. Springer Verlag. 1212-1215. 2008
Journal Articles Refereed
- Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet. International Journal of Obesity. 32:249-258. 2008
- Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations1-3. American Journal of Clinical Nutrition. 87:1238-1246. 2008
- Gastrin is not required for liver regeneration. ANZ Journal of Surgery. 78:68-71. 2008
- Interrelationships between circulating gastrin and iron status in mice and humans. American Journal of Physiology - Gastrointestinal and Liver Physiology. 295:G855-G861. 2008
- Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by gastrins. Cellular Signaling. 20:83-93. 2008
- PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins. Biochimica et Biophysica Acta - Molecular Cell Research. 1783:1943-1954. 2008
2007
Journal Articles Refereed
- Beta-Catenin/Tcf-4 inhibition after prograstrin targeting reduces growth and drives differentiation of intestinal tumors. Gastroenterology. 133:1554-1568. 2007
- c-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor. Endocrinology. 148:1330-1339. 2007
- cck receptors and cancer. Current Topics in Medicinal Chemistry. 7:1232-1238. 2007
- phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications. Regulatory Peptides. 143:1-14. 2007
- recombinant c-terminal fragments of the gastrin-releasing peptide precursor are bioactive. Cancer Letters. 254:87-93. 2007
2006
Book Chapters Other
- Regulation of gastric acid secretion. Physiology of the Gastrointestinal Tract. Elsevier Science. 1223-1258. 2006
Journal Articles Refereed
- An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 290:R625-R633. 2006
- Circulating gastrin is increased in hemochromatosis. FEBS Letters. 580:6195-6198. 2006
- Gastrin-releasing peptide and cancer. BBA - Reviews on Cancer. 1766:23-41. 2006
- Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo.. Regulatory Peptides. 134:9-16. 2006
- Production, Secretion, and Biological Activity of the C-Terminal Flanking Peptide of Human Progastrin. Gastroenterology. 131:1463-1474. 2006
- Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP).. Endocrinology. 147:502-509. 2006
2005
Journal Articles Refereed
- Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.. American Journal of Physiology - Gastrointestinal and Liver Physiology. 289:G478-G488. 2005
- The effect of lipopolysaccharide one cholecystokinin in murine plasma and tissue. Peptides. 26:447-455. 2005
Journal Articles Unrefereed
- Signalling junctions in the gut epithelium.. Signal Transduction Knowledge Environment. 277:pe13-pe13. 2005
2004
Book Chapters Other
- Gastrin processing patterns: ontogeny, phylogeny and pathology. Gastrin in the new millennium. Cure Foundation. 33-38. 2004
Journal Articles Refereed
- A novel effect of bismuth ions - Selective inhibition of the biological activity of glycine-extended gastrin. Journal of Biological Chemistry. 279:2453-2460. 2004
- Biological activity and ferric ion binding of fragments of glycine-extended gastrin. Biochemistry. 43:11853-11861. 2004
- Developmental expression and biological activity of gastrin-releasing peptide (GRP) and GRP receptors in the kidney. American Journal of Physiology: Renal Physiology. 287:F578-F585. 2004
- Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins. Journal of Endocrinology. 181:315-325. 2004
- Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology. 126:196-207. 2004
- Gastrins, cholecystokinins and gastrointestinal cancer. BBA - Reviews on Cancer. 1704:1-10. 2004
- Identity and regulation of stored and secreted progastrin-derived peptides in sheep. Endocrinology. 145:5129-5140. 2004
- PPARΑ agonists stimulate progastrin production in human colorectal carcinoma cells. Regulatory Peptides. 120:243-251. 2004
- Regulation of expression of the receptors controlling gastric acidity. Regulatory Peptides. 121:1-9. 2004
- Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor. Biochemical Pharmacology. 68:2129-2142. 2004
Major Reference Works
- Encyclopedia of Gastroenterology. Edition. 1 2004
- Neurotensin. Edition. 3 2004
Patents
- Method of treatment 2004
2002
Book Chapters Other
- Gastrin-somatostatin interactions: from ontogeny to pathology. Gut-brain peptides in the New Millennium. Cure Foundation. 31-38. 2002
Journal Articles Refereed
- Antropyloroduodenal, cholecystokinin and feeding responses to pulsatile and non-pulsatile intraduodenal lipid infusion. Neurogastroenterology and Motility. 14:25-35. 2002
- Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin. Journal of Biological Chemistry. 277:48602-48609. 2002
- Isolation and characterisation of the ovine gastrin-releasing peptide gene; abundant expression in the pregnant uterus and selective expression in fetal tissues. Journal of Endocrinology. 175:447-457. 2002
- Maturational and maintenance effects of testosterone on terminal axon density and neuropeptide expression in the rat vas deferens. Neuroscience. 112:391-398. 2002
- Metabolism of recombinant progastrin in sheep. American Journal of Physiology - Endocrinology and Metabolism. 283:E449-E456. 2002
- Preparation of biologically active recombinant human progastrin1-80. Journal of Protein Chemistry. 21:465-471. 2002
2001
Journal Articles Refereed
- Biology and pathology of non-amidated gastrins. Scandinavian Journal of Clinical and Laboratory Investigation. 61:123-128. 2001
- Expression of receptors regulating gastric acidity in the developing sheep stomach. Regulatory Peptides. 101:93-100. 2001
- Identification of a 70-kDa gastrin-binding protein on DLD-1 human colorectal carcinoma cells. International Journal of Biochemistry and Cell Biology. 33:1071-1079. 2001
- Short term infusion of glycine-extended gastrin17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. International Journal of Cancer. 94:307-313. 2001
Other Refereed Contribution to Refereed Journals
- Regulatory peptides: what do they regulate?. Trends in Endocrinology and Metabolism. 12:46-47. 2001
Research
Investigator on
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Contract
- BIOLOGY AND PATHOLOGY OF GASTRIN RELEASING PEPTIDE (GRP) awarded by BOSTON UNIVERSITY 2009 -
- MTA - THE ROLE OF GASTRIN-RELEASING PEPTIDE IN RENAL CELL CARCINOMA awarded by MEMORIAL SLOAN-KETTERING CANCER CENTER 2007 -
- DO PANCREATIC STELLATE CELLS PLAY A ROLE IN PANCREATIC EXOCRINE SECRETION (Discovery Projects) awarded by UNIVERSITY OF NEW SOUTH WALES - DO NOT USE (636)
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Grant
- Targetting the Kinase PAK1 in Colorectal Cancer (Project Grants) awarded by NHMRC 2013 - 2015
- Targetting proGRP as a therapeutic strategy for gastrointestinal cancers (Grants-in-Aid) awarded by CANCER COUNCIL VICTORIA 2013 - 2014
- Role of gastrin prohormones in the development of gastrointestinal cancers (Project Grants) awarded by NHMRC 2011 - 2013
- Mechanisms of renin angiotensin system-regulated growth of colorectal liver metastases (Grants-in-Aid) awarded by CANCER COUNCIL VICTORIA 2011 - 2012
- Role of the Growth Factor ProGRP in the Development of Gastrointestinal Cancers (Project Grants) awarded by NHMRC 2010 - 2012
- Ischaemic preconditioning of the kidney by activation of hypoxia inducible Factor 1a (Foundation for Surgery Research Scholarship) awarded by ROYAL AUSTRALASIAN COLLEGE OF SURGEONS 2010 - 2011
- Gastrin, Iron and Colorectal Cancer (Project Grants) awarded by NHMRC 2009 - 2011
- HIGH PRESSURE BINARY LIQUID CHROMATOGRAPHY SYSTEM (Equipment Grant) awarded by PROSTATE CANCER FOUNDATION OF AUST 2009
- Physiology and pathology of novel forms of progastrin (Project Grants) awarded by NHMRC 2008 - 2011
- ProGRP as a biomarker for prostate cancer (Grants-in-Aid) awarded by CANCER COUNCIL VICTORIA 2008 - 2010
- Biology of GRP precursors (Project Grants) awarded by NHMRC 2007 - 2010
- Role of GRP in Prostate Cancer (Medical Research Grants) awarded by SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION 2007 - 2008
- THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES (Research Project Grants) awarded by NATIONAL INSTITUTE OF HEALTH 2006 - 2011
- THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES (Project Grants) awarded by NHMRC 2006 - 2009
- MECHANISMS OF ACTION OF THERMAL ABLATION ON COLORECTAL LIVER METASTASES (Grants-in-Aid) awarded by CANCER COUNCIL VICTORIA 2006 - 2007
- Senior Principal Research Fellowship Renewal (Research Fellowship) awarded by NHMRC 2005 - 2009
- PROGASTRIN DERIVED PEPTIDES: BIOLOGICAL ACTIVITIES AND FUNCTIONS IN THE GASTROINTESTINAL TRACT (Project Grants) awarded by NHMRC 2005 - 2007
- Bombesin like peptides as autocrine growth factors in colorectal cancer (Project Grants) awarded by NHMRC 2002 - 2005
- Functional relationships of gastrin and its regulators in the developing and diseased gastrointestinal tracts (Research Fellowship) awarded by NHMRC 2001 - 2005
- Functional relationships of gastrin and its regulators in the developing and diseased gastrointestinal tracts (Project Grants) awarded by NHMRC 2000 - 2005
Awards
Education and training
- DSc, University of Melbourne 1995
- PhD, University of Melbourne 1975
- BSc, University of Melbourne 1970
Awards and honors
- Equity and Staff Development Award, University of Melbourne, 2008
- Distinguished Research Prize of the Gastroenterological Society of Australia, Gastroenterological Society of Australia, 2008
- Austin Hospital Research Foundation Distinguished Scientist Award., Austin Health, 2004
Linkages
International Linkage
- Institut National de la Sante et de la Recherche Medicale (Exchange; Research)
- Columbia University College of Physicians and Surgeons (Research)
- University of Liverpool (Research)
Supervision
Available for supervision
- Y
- Contact Details
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aas@unimelb.edu.au
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8344 9001
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Location
- Level: 02 Room: 221, Alan Gilbert Building, Parkville
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