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DR THOMAS GEBHARDT

Positions

Academic, Microbiology and Immunology

Affiliation

Member of

Australasian Society of Immunology. Member 2005 -
German Society of Immunology. Member 2005 -

Publications

Selected publications

2012
- Journal Articles Refereed
  - Long-lived epithelial immunity by tissue-resident memory T (T_RM ) cells in the absence of persisting local antigen presentation. Proceedings of the National Academy of Sciences of the United States of America. 109:7037-7042. 2012
  - NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells. Nature Immunology. 13:162-169. 2012
2011
- Journal Articles Refereed
  - Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells. Nature. 477:216-219. 2011
  - Interaction between dendritic cells and T cells during peripheral virus infections: a role for antigen presentation beyond lymphoid organs?. Current Opinion in Immunology. 23:124-130. 2011
2009
- Journal Articles Refereed
  - Characterization of an Immediate Splenic Precursor of CD8⁺ Dendritic Cells Capable of Inducing Antiviral T Cell Responses. Journal of Immunology. 182:4200-4207. 2009
  - Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection. European Journal of Immunology. 39:1203-1210. 2009
  - Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nature Immunology. 10:524-530. 2009
- Other Refereed Contribution to Refereed Journals
  - Immunology: A helpers' guide to infection. Nature. 462:418-419. 2009
2008
- Journal Articles
  - Neuropeptide Y receptor-specifically modulates human neutrophil function. Journal of Neuroimmunology. 195:88-95. 2008
- Journal Articles Refereed
  - CD8⁺ T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection. Immunology and Cell Biology. 86:666-675. 2008
  - Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues. Journal of Immunology. 181:5837-5841. 2008
  - Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoimmunity. Journal of Immunology. 180:5789-5793. 2008
2007
- Journal Articles Refereed
  - A role for neuropeptide Y (NPY) in phagocytosis: implications for innate and adaptive immunity. Peptides. 28:373-376. 2007
2006
- Journal Articles
  - Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease. Advances in Experimental Medicine and Biology. 579:177-208. 2006
2005
- Journal Articles Refereed
  - Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1. Gut. 54:928-934. 2005
  - beta2-Adrenoceptor-mediated suppression of human intestinal mast cell functions is caused by disruption of filamentous actin dynamics. European Journal of Immunology. 35:1124-1132. 2005
2004
- Journal Articles Refereed
  - Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor.. Journal of Immunology. 172:260-267. 2004
  - Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. Journal of Neuroimmunology. 155:1-12. 2004
2003
- Journal Articles Refereed
  - Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells. Journal of Allergy and Clinical Immunology. 111:1062-1068. 2003
2002
- Journal Articles Refereed
  - Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release.. European Journal of Immunology. 32:2308-2316. 2002
  - Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors. Gastroenterology. 123:608-618. 2002
  - NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobiliza. Journal of Neuroimmunology. 132:25-33. 2002

Research

Investigator on

Grant
- THE ROLE OF CD4+ T CELLS IN IMMUNITY TO HSV-1 (Project Grants) awarded by NHMRC 2011 - 2013
- Effective Immune Protection in Peripheral Organs (Career Development Awards) awarded by NHMRC 2010 - 2013
- Effective T cell memory in peripheral organs (Project Grants) awarded by NHMRC 2010 - 2012
- A NOVEL STRATEGY OF T CELL-BASED VACCINATION AGAINST PERIPHERAL VIRUS INFECTION (Melbourne Research Grants Support Scheme) awarded by UNIVERSITY OF MELBOURNE

Awards

Education and training

PhD, Hannover Medical School 2005
MD, Hannover Medical School 2004
License, Hannover Medical School 2002

Awards and honors

Postdoctoral Fellowship, German Research Foundation, 2005

Supervision

Available for supervision

Y

Contact Details
- gebhardt@unimelb.edu.au
- 8344-6132
- fax: 9347-1540
- Location
  - Level: 05 Room: 5.19, Microbiology Building, Parkville
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